Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment

• Published in: Annals of the Rheumatic Diseases Vol. 65; no. 2; pp. 144 - 148
• Main Authors: Giannouli, S, Voulgarelis, M, Ziakas, P D, Tzioufas, A G
• Format: Journal Article Book Review
• Language: English
• Published: London BMJ Publishing Group Ltd and European League Against Rheumatism 01.02.2006; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: ACD; aCL; AHA; anaemia; anaemia of chronic disease; Anemia, Hemolytic, Autoimmune - drug therapy; Anemia, Hemolytic, Autoimmune - etiology; Anemia, Hemolytic, Autoimmune - immunology; Anemias. Hemoglobinopathies; anticardiolipin antibodies; Anticoagulants; Antigens; antiphospholipid syndrome; APS; Autoantibodies - immunology; autoimmune haemolytic anaemia; Biological and medical sciences; bone marrow; Chronic illnesses; diagnostic approach; Diseases of red blood cells; Diseases of the osteoarticular system; EPO; erythropoietin; Erythropoietin - immunology; Erythropoietin - therapeutic use; Hematologic and hematopoietic diseases; Hematology; Hematopoiesis; Humans; IDA; IFN; Immunoglobulins; interferon; iron deficiency anaemia; Lupus; Lupus Erythematosus, Systemic - drug therapy; Lupus Erythematosus, Systemic - immunology; Medical sciences; Pathogenesis; Plasma; PRCA; Proteins; pure red cell aplasia; recombinant human erythropoietin; Recombinant Proteins; Review; rHuEPO; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; SLE; systemic lupus erythematosus; T-Lymphocytes - immunology; TNFα; tumour necrosis factor α; Connective tissue disease; Skin disease; Systemic lupus erythematosus; Pathophysiology; Anemia; Systemic disease; Rheumatology; Autoimmune disease; Hemopathy

Haematological abnormalities are common in systemic lupus erythematosus. Anaemia is found in about 50% of patients, with anaemia of chronic disease being the most common form. Impaired erythropoietin response and presence of antibodies against erythropoietin may contribute to the pathogenesis of thi...