Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal - Dai, S-M; Shan, Z-Z; Nishioka, K; Yudoh, K (Annals of the rheumatic diseases, 2005)
Keywords: ADAM Proteins; ADAMTS5 Protein; Adult; Aged; Aged, 80 and over; Arthritis; Arthritis - enzymology; Arthritis - metabolism; Arthritis - pathology; Arthritis, Rheumatoid - enzymology; Arthritis, Rheumatoid - metabolism; Arthritis, Rheumatoid - pathology; articular cartilage; Bacterial arthritis and osteitis; Bacterial diseases; Biological and medical sciences; c-Jun N-terminal kinase; Cartilage, Articular - enzymology; Cartilage, Articular - pathology; Cells, Cultured; chondrocytes; Chondrocytes - drug effects; Chondrocytes - enzymology; Chondrocytes - metabolism; Collagen; Cytokines; Deoxyribonucleic acid; Diseases of the osteoarticular system; DMEM; DNA; Dulbecco’s modified Eagle’s medium; ELISA; enzyme linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; Extended Report; Extracellular matrix; GAPDH; Gene Expression Regulation - drug effects; glyceraldehyde-3-phosphate dehydrogenase; Human bacterial diseases; Humans; IL18R; Infectious diseases; interleukin; interleukin 18; interleukin 18 receptor; Interleukin-18 - biosynthesis; Interleukin-18 - genetics; Interleukin-18 - pharmacology; JNK; Joint surgery; Kinases; MAPK; matrix metalloproteinase; Matrix Metalloproteinases - biosynthesis; Medical sciences; MEK; Metalloendopeptidases - biosynthesis; Metalloendopeptidases - genetics; metalloproteinases; Middle Aged; Miscellaneous. Osteoarticular involvement in other diseases; mitogen activated protein kinase; mitogen activated protein kinase/extracellular signal regulated kinase kinase; MMP; NF-κB; nuclear factor κB; osteoarthritis; Osteoarthritis - enzymology; Osteoarthritis - metabolism; Osteoarthritis - pathology; PGE2; prostaglandin E2; Proteins; Reverse Transcriptase Polymerase Chain Reaction - methods; reverse transcriptase-polymerase chain reaction; rheumatoid arthritis; RNA, Messenger - genetics; Rodents; RT-PCR; Signal Transduction; Studies; TIMPs; Tissue Inhibitor of Metalloproteinase-1 - biosynthesis; tissue inhibitors of metalloproteinases; TNFα; tumour necrosis factor α; Japan; Arthritis; Chondrocyte; Diseases of the osteoarticular system; Production; Interleukin 18