The growth hormone–insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders

• Published in: Endocrine Connections Vol. 7; no. 6; pp. R212 - R222
• Main Authors: Blum, Werner F, Alherbish, Abdullah, Alsagheir, Afaf, El Awwa, Ahmed, Kaplan, Walid, Koledova, Ekaterina, Savage, Martin O
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.06.2018; Bioscientifica
• Subjects: binding protein-3; growth hormone; insulin-like growth factor; insulin-like growth factor-I; paediatrics; Review; short stature; paediatrics; insulin-like growth factor-I; short stature; binding protein-3; insulin-like growth factor; growth hormone

The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the components of the IGF system are less current in...