The growth hormone–insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders

The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the components of the IGF system are less current in...

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Published inEndocrine Connections Vol. 7; no. 6; pp. R212 - R222
Main Authors Blum, Werner F, Alherbish, Abdullah, Alsagheir, Afaf, El Awwa, Ahmed, Kaplan, Walid, Koledova, Ekaterina, Savage, Martin O
Format Journal Article
LanguageEnglish
Published England Bioscientifica Ltd 01.06.2018
Bioscientifica
Subjects
binding protein-3
growth hormone
insulin-like growth factor
insulin-like growth factor-I
paediatrics
Review
short stature
paediatrics
insulin-like growth factor-I
short stature
binding protein-3
insulin-like growth factor
growth hormone
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Abstract The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the components of the IGF system are less current in clinical practice. The physiological function of this axis is to increase the anabolic cellular processes of protein synthesis and mitosis, and reduction of apoptosis, with each being regulated in the appropriate target tissue. Measurement of serum IGF-I and IGF-binding protein (IGFBP)-3 concentrations can complement assessment of GH status in the investigation of short stature and contribute to prediction of growth response during GH therapy. IGF-I monitoring during GH therapy also informs the clinician about adherence and provides a safety reference to avoid over-dosing during long-term management.
AbstractList The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the components of the IGF system are less current in clinical practice. The physiological function of this axis is to increase the anabolic cellular processes of protein synthesis and mitosis, and reduction of apoptosis, with each being regulated in the appropriate target tissue. Measurement of serum IGF-I and IGF-binding protein (IGFBP)-3 concentrations can complement assessment of GH status in the investigation of short stature and contribute to prediction of growth response during GH therapy. IGF-I monitoring during GH therapy also informs the clinician about adherence and provides a safety reference to avoid over-dosing during long-term management.
The growth hormone (GH)-insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the components of the IGF system are less current in clinical practice. The physiological function of this axis is to increase the anabolic cellular processes of protein synthesis and mitosis, and reduction of apoptosis, with each being regulated in the appropriate target tissue. Measurement of serum IGF-I and IGF-binding protein (IGFBP)-3 concentrations can complement assessment of GH status in the investigation of short stature and contribute to prediction of growth response during GH therapy. IGF-I monitoring during GH therapy also informs the clinician about adherence and provides a safety reference to avoid over-dosing during long-term management.The growth hormone (GH)-insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the components of the IGF system are less current in clinical practice. The physiological function of this axis is to increase the anabolic cellular processes of protein synthesis and mitosis, and reduction of apoptosis, with each being regulated in the appropriate target tissue. Measurement of serum IGF-I and IGF-binding protein (IGFBP)-3 concentrations can complement assessment of GH status in the investigation of short stature and contribute to prediction of growth response during GH therapy. IGF-I monitoring during GH therapy also informs the clinician about adherence and provides a safety reference to avoid over-dosing during long-term management.
Author Alherbish, Abdullah
El Awwa, Ahmed
Savage, Martin O
Blum, Werner F
Alsagheir, Afaf
Koledova, Ekaterina
Kaplan, Walid
AuthorAffiliation Al Habib Medical Group, Riyadh, Saudi Arabia
Global Medical Affairs Endocrinology, Merck KGaA, Darmstadt, Germany
Tawam Hospital, Al Ain, UAE
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, London, UK
Department of Pediatric Endocrinology & Diabetes, Hamad Medical Center, Doha, Qatar
University Children’s Hospital, Giessen, Germany
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– name: Al Habib Medical Group, Riyadh, Saudi Arabia
– name: Department of Pediatric Endocrinology & Diabetes, Hamad Medical Center, Doha, Qatar
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– name: King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
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  email: m.o.savage@qmul.ac.uk
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insulin-like growth factor-I
short stature
binding protein-3
insulin-like growth factor
growth hormone
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Snippet The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a...
The growth hormone (GH)-insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a...
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SubjectTerms binding protein-3
growth hormone
insulin-like growth factor
insulin-like growth factor-I
paediatrics
Review
short stature
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Title The growth hormone–insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders
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