The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice

• Published in: Biology of reproduction Vol. 100; no. 2; pp. 429 - 439
• Main Authors: Serra, Nicholas, Velte, Ellen K, Niedenberger, Bryan A, Kirsanov, Oleksander, Geyer, Christopher B
• Format: Journal Article
• Language: English
• Published: United States Society for the Study of Reproduction 01.02.2019; Oxford University Press
• Subjects: Adult Germline Stem Cells - metabolism; Animals; Epididymis - cytology; fertility; Gene Expression Regulation - physiology; Infertility; Male; Male identity; Mechanistic Target of Rapamycin Complex 1 - genetics; Mechanistic Target of Rapamycin Complex 1 - metabolism; Meiosis; Mice; Mice, Knockout; Mtor; mTORC1; Physiological aspects; Physiological research; Protein kinases; Proteins; Regulatory-Associated Protein of mTOR - genetics; Regulatory-Associated Protein of mTOR - metabolism; Reproductive health; Rptor; Sperm; Spermatogenesis; Spermatozoa - physiology; Stem cells; Testis; Tumors; United States; spermatogenesis; testis; mTORC1; fertility; Rptor; Mtor
• ISSN: 0006-3363; 1529-7268; 1529-7268
• DOI: 10.1093/biolre/ioy198

The self-renewal, proliferation, and differentiation of the spermatogonial populations must be finely coordinated in the mammalian testis, as dysregulation of these processes can lead to subfertility, infertility, or the formation of tumors. There are wide gaps in our understanding of how these sper...