Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution - Emoto, Chie; Murayama, Norie; Rostami-Hodjegan, Amin; Yamazaki, Hiroshi (Current drug metabolism, 2010)
Keywords: Adult; Animals; Cytochrome P-450 Enzyme System - metabolism; Drug Design; Drug Discovery - methods; Drug Industry - methods; Drug-Related Side Effects and Adverse Reactions; Humans; Liver - enzymology; Liver - metabolism; Microsomes, Liver - metabolism; Pharmaceutical Preparations - metabolism; Protein Binding