Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice - Fortner, Karen A; Blanco, Luz P; Buskiewicz, Iwona; Huang, Nick; Gibson, Pamela C; Cook, Deborah L; Pedersen, Hege L; Yuen, Peter S T; Murphy, Michael P; Perl, Andras; Kaplan, Mariana J; Budd, Ralph C (Lupus science & medicine, 2020)
Keywords: Animal Models; Animals; Antiviral drugs; Autoantibodies - metabolism; autoimmune diseases; Disease Models, Animal; Drinking water; Extracellular Traps - immunology; Female; Flow cytometry; Humans; Immunoglobulins; inflammation; Interferon Type I - immunology; Kidney - metabolism; Kidney - physiopathology; Kidney Diseases - metabolism; Kidney Diseases - physiopathology; Kidneys; Laboratory animals; Lupus; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - physiopathology; Lymphatic system; Lymphocytes; Male; Medical disciplines: 700; Medisinske Fag: 700; Metabolism; Mice; Mice, Inbred MRL lpr; Microscopy; Mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Neutrophils; Neutrophils - immunology; Organophosphorus Compounds - pharmacology; Oxidation-Reduction - drug effects; Oxidative stress; Oxidative Stress - immunology; Proteins; Reactive Oxygen Species - metabolism; systemic lupus erythematosus; T cells; T-Lymphocytes - immunology; Ubiquinone - analogs & derivatives; Ubiquinone - pharmacology; VDP; Oregon; California; United States--US; Texas; Pennsylvania; autoimmune diseases; systemic lupus erythematosus; T cells; inflammation