Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders

• Published in: CNS & neurological disorders drug targets Vol. 14; no. 6; p. 745
• Main Authors: Roberts-Wolfe, Douglas J, Kalivas, Peter W
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2015
• Subjects: Acetylcysteine - pharmacology; Acetylcysteine - therapeutic use; Animals; Ceftriaxone - pharmacology; Ceftriaxone - therapeutic use; Excitatory Amino Acid Transporter 2 - metabolism; Glutamic Acid - metabolism; Humans; Neurotransmitter Uptake Inhibitors - therapeutic use; Substance-Related Disorders - therapy

The development of new treatments for substance use disorders requires identification of targetable molecular mechanisms. Pathology in glutamatergic neurotransmission system in brain reward circuitry has been implicated in relapse to multiple classes of drugs. Glutamate transporter 1 (GLT-1) crucial...