S100A8 and S100A9 in experimental osteoarthritis

• Published in: Arthritis research & therapy Vol. 12; no. 1; p. R16
• Main Authors: Zreiqat, Hala, Belluoccio, Daniele, Smith, Margaret M, Wilson, Richard, Rowley, Lynn A, Jones, Katie, Ramaswamy, Yogambha, Vogl, Thomas, Roth, Johannes, Bateman, John F, Little, Christopher B
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.01.2010; BioMed Central
• Subjects: Animals; Arthritis, Experimental - genetics; Arthritis, Experimental - metabolism; Arthritis, Experimental - pathology; Calcium-binding proteins; Calgranulin A; Calgranulin B - biosynthesis; Cartilage - metabolism; Cartilage - pathology; Cartilage cells; Chondrocytes - metabolism; Development and progression; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genetic aspects; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Osteoarthritis; Osteoarthritis - genetics; Osteoarthritis - metabolism; Osteoarthritis - pathology; Physiological aspects; Research article; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; S100 Proteins - biosynthesis

The objective was to evaluate the changes in S100A8 S100A9, and their complex (S100A8/S100A9) in cartilage during the onset of osteoarthritis (OA) as opposed to inflammatory arthritis. S100A8 and S100A9 protein localization were determined in antigen-induced inflammatory arthritis in mice, mouse fem...