Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice

• Published in: Arthritis research & therapy Vol. 11; no. 5; p. R132
• Main Authors: Bian, Li, Josefsson, Elisabet, Jonsson, Ing-Marie, Verdrengh, Margareta, Ohlsson, Claes, Bokarewa, Maria, Tarkowski, Andrej, Magnusson, Mattias
• Format: Journal Article
• Language: English
• Published: England National Library of Medicine - MEDLINE Abstracts 01.01.2009; BioMed Central Ltd; BioMed Central
• Subjects: Animals; Arthritis, Experimental - immunology; Arthritis, Experimental - pathology; Arthritis, Experimental - prevention & control; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - pathology; Autoantibodies - blood; Autoantibodies - drug effects; Bone Density - drug effects; Collagen - immunology; Dichloroacetic Acid - therapeutic use; Endocrinology and Diabetes; Endokrinologi och diabetes; Estrogens - metabolism; Female; Fysiologi; Hypersensitivity, Delayed - drug therapy; Hypersensitivity, Delayed - immunology; MEDICIN; MEDICINE; Mice; Mice, Inbred DBA; Ovariectomy; Physiology; Research article; Reumatologi och inflammation; Rheumatology and Autoimmunity; T-Lymphocytes - drug effects; TECHNOLOGY; TEKNIKVETENSKAP

Dichloroacetate (DCA) has been in clinical use for the treatment of lactacidosis and inherited mitochondrial disorders. It has potent anti-tumor effects both in vivo and in vitro, facilitating apoptosis and inhibiting proliferation. The pro-apoptotic and anti-proliferative properties of DCA prompted...