Adiponectin is a potential catabolic mediator in osteoarthritis cartilage

• Published in: Arthritis research & therapy Vol. 12; no. 6; p. R231
• Main Authors: Kang, Eun Ha, Lee, Yun Jong, Kim, Tae Kyun, Chang, Chong Bum, Chung, Jin-Haeng, Shin, Kichul, Lee, Eun Young, Lee, Eun Bong, Song, Yeong Wook
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.01.2010; BioMed Central
• Subjects: Adiponectin - metabolism; Adipose tissues; Aged; Aged, 80 and over; Blotting, Western; Cartilage, Articular - metabolism; Collagenases - metabolism; Cytokines - metabolism; Development and progression; Female; Humans; Immunohistochemistry; Inflammation; Matrix Metalloproteinases - metabolism; Mediators; Middle Aged; Nitric Oxide Synthase Type II - metabolism; Osteoarthritis; Osteoarthritis - metabolism; Physiological aspects; Receptors, Adiponectin - biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction - physiology

Adiponectin has been implicated in the pathogenesis of osteoarthritis (OA). We studied the effects of adiponectin on the OA cartilage homeostasis. Immunohistochemical analysis was performed to evaluate differential expression of adiponectin receptors (AdipoRs) in nonlesional and lesional areas of OA...