Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice

• Published in: European journal of endocrinology Vol. 146; no. 5; pp. 717 - 727
• Main Authors: Reimer, MK, Holst, JJ, Ahren, B
• Format: Journal Article
• Language: English
• Published: Colchester European Society of Endocrinology 01.05.2002; Portland Press
• Subjects: Animal; Animals; Antigens; Biological and medical sciences; Blood Glucose - analysis; Body Weight; CD26 : blood; CD26 : drug effects; Clinical Medicine; Dietary Fats - administration & dosage; Dipeptidyl Peptidase 4 - blood; Dipeptidyl Peptidase 4 - drug effects; Drinking; Eating; Endocrine pancreas; Endocrinology and Diabetes; Endokrinologi och diabetes; Female; Fundamental and applied biological sciences. Psychology; Gastrointestinal; Glucagon - blood; Glucagon-Like Peptide 1; Glucose - administration & dosage; Glucose - pharmacology; Glucose Intolerance - drug therapy; Hormones. Régulation; Inbred C57BL; Insulin - blood; Insulin Resistance - physiology; Intubation; Intubation, Gastrointestinal; Islets of Langerhans - anatomy & histology; Islets of Langerhans - drug effects; Islets of Langerhans - physiology; Klinisk medicin; Medical and Health Sciences; Medicin och hälsovetenskap; Mice; Mice, Inbred C57BL; Nitriles - therapeutic use; Non-U.S. Gov't; Organ Size - drug effects; Organ Weight : drug effects; Peptide Fragments - blood; Protease Inhibitors - therapeutic use; Protein Precursors - blood; Pyrrolidines - therapeutic use; Support; Time Factors; Vertebrates: endocrinology; Dipeptidyl-peptidase IV; Stomach; Glucagon; Enzyme; Immunocytochemistry; Rodentia; Langerhans islet; Tolerance; Selectivity; Glucose; Long term; Glucagon like peptide 1; Peptidases; Vertebrata; Mammalia; Treatment; Mouse; Animal; Hydrolases; Inhibitor; Inhibition

OBJECTIVES: Inhibitors of the glucagon-like peptide-1 (GLP-1)-degrading enzyme, dipeptidyl peptidase IV (DPPIV), are being explored in the treatment of diabetes. We examined the long-term influence of a selective, orally active inhibitor of DPPIV (NVP DPP728), in normal female C57BL/6J mice and such...