Functional annotation by identification of local surface similarities: a novel tool for structural genomics

• Published in: BMC bioinformatics Vol. 6; no. 1; p. 194
• Main Authors: Ferrè, Fabrizio, Ausiello, Gabriele, Zanzoni, Andreas, Helmer-Citterich, Manuela
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.08.2005; BioMed Central; BMC
• Subjects: Algorithms; Binding Sites; Computational Biology; Databases, Protein; False Negative Reactions; Genomics - methods; Information Storage and Retrieval - methods; Internet; Methodology; Molecular Sequence Data; Pattern Recognition, Automated; Proteins - chemistry; Proteins - classification; Proteins - metabolism; Sequence Analysis, Protein - methods

Protein function is often dependent on subsets of solvent-exposed residues that may exist in a similar three-dimensional configuration in non homologous proteins thus having different order and/or spacing in the sequence. Hence, functional annotation by means of sequence or fold similarity is not ad...