Inflammatory and cytotoxic effects of acrolein, nicotine, acetylaldehyde and cigarette smoke extract on human nasal epithelial cells

• Published in: BMC pulmonary medicine Vol. 14; no. 1; p. 32
• Main Authors: Comer, David M, Elborn, Joseph Stuart, Ennis, Madeleine
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.03.2014; BioMed Central
• Subjects: Acetaldehyde - adverse effects; Acrolein - adverse effects; Analysis; Apoptosis; Cell culture; Cell death; Cell Death - drug effects; Cells, Cultured; Chemical properties; Chronic obstructive pulmonary disease; Epithelial Cells - drug effects; Health aspects; Humans; Inflammation - chemically induced; Nasal Mucosa - cytology; Nasal Mucosa - drug effects; Nicotiana - adverse effects; Nicotine - adverse effects; Pulmonology; Respiratory diseases; Smoke - adverse effects; Tobacco smoke

Cigarette smoke induces a pro-inflammatory response in airway epithelial cells but it is not clear which of the various chemicals contained within cigarette smoke (CS) should be regarded as predominantly responsible for these effects. We hypothesised that acrolein, nicotine and acetylaldehyde, impor...