Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations

• Published in: Thorax Vol. 73; no. 5; pp. 422 - 430
• Main Authors: Mayhew, David, Devos, Nathalie, Lambert, Christophe, Brown, James R, Clarke, Stuart C, Kim, Viktoriya L, Magid-Slav, Michal, Miller, Bruce E, Ostridge, Kristoffer K, Patel, Ruchi, Sathe, Ganesh, Simola, Daniel F, Staples, Karl J, Sung, Ruby, Tal-Singer, Ruth, Tuck, Andrew C, Van Horn, Stephanie, Weynants, Vincent, Williams, Nicholas P, Devaster, Jeanne-Marie, Wilkinson, Tom M A
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.05.2018; BMJ Publishing Group
• Series: Original article
• Subjects: Aged; Antibiotics; Bacteria; Chronic Obstructive Pulmonary Disease; Disease; Disease Progression; Female; Gene amplification; Haemophilus - isolation & purification; Humans; Infections; Longitudinal Studies; Lung - microbiology; Male; Microbiota; Middle Aged; Moraxella - isolation & purification; Observational Studies as Topic; Phenotype; Prevotella - isolation & purification; Pulmonary Disease, Chronic Obstructive - microbiology; Pulmonary Disease, Chronic Obstructive - pathology; Pulmonary Disease, Chronic Obstructive - virology; Pulmonary Eosinophilia - complications; Pulmonary Eosinophilia - pathology; Recurrence; RNA, Ribosomal, 16S - analysis; Severity of Illness Index; Sputum - cytology; Sputum - microbiology; Streptococcus - isolation & purification; Veillonella - isolation & purification; Viral infections; Copd exacerbations; respiratory infection; Copd ÀÜ mechanisms

BackgroundAlterations in the composition of the lung microbiome associated with adverse clinical outcomes, known as dysbiosis, have been implicated with disease severity and exacerbations in COPD.ObjectiveTo characterise longitudinal changes in the lung microbiome in the AERIS study (Acute Exacerbat...