Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders

• Published in: Molecular autism Vol. 4; no. 1; p. 30
• Main Authors: Stamova, Boryana S, Tian, Yingfang, Nordahl, Christine W, Shen, Mark D, Rogers, Sally, Amaral, David G, Sharp, Frank R
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.09.2013; BioMed Central
• Subjects: Autistic children; Comparative analysis; Computer software industry; Gene expression; Genes; Genetic aspects; Genomes; Glutathione transferase; Medical genetics; Molecular genetics; Pervasive developmental disorders; RNA splicing; Superoxide; United States

Since RNA expression differences have been reported in autism spectrum disorder (ASD) for blood and brain, and differential alternative splicing (DAS) has been reported in ASD brains, we determined if there was DAS in blood mRNA of ASD subjects compared to typically developing (TD) controls, as well...