Isoniazid: metabolic aspects and toxicological correlates

• Published in: Current drug metabolism Vol. 8; no. 8; p. 839
• Main Author: Preziosi, Paolo
• Format: Journal Article
• Language: English
• Published: Netherlands 01.12.2007
• Subjects: Antitubercular Agents - metabolism; Antitubercular Agents - toxicity; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; Isoniazid - chemistry; Isoniazid - metabolism; Isoniazid - pharmacokinetics; Isoniazid - toxicity; MEDLINE

For over half a century, pyridine-4-carboxy hydrazide (isonicotinyl hydrazide; isoniazid - INH) has been a front-line weapon in the battle against tuberculosis. Its metabolism has been the subject of important research, much of which has focused on the pharmacodynamic and toxicological aspects of ce...