Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time

• Published in: Gut Vol. 69; no. 3; pp. 502 - 512
• Main Authors: de Groot, Pieter, Scheithauer, Torsten, Bakker, Guido J, Prodan, Andrei, Levin, Evgeni, Khan, Muhammad Tanweer, Herrema, Hilde, Ackermans, Mariette, Serlie, Mireille J M, de Brauw, Maurits, Levels, Johannes H M, Sales, Amber, Gerdes, Victor E, Ståhlman, Marcus, Schimmel, Alinda W M, Dallinga-Thie, Geesje, Bergman, Jacques JGHM, Holleman, Frits, Hoekstra, Joost B L, Groen, Albert, Bäckhed, Fredrik, Nieuwdorp, Max
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.03.2020; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Adipose tissue; Adult; Aged; Bile; bile acid metabolism; Bile acids; Bile Acids and Salts - analysis; Chemokine CCL2 - blood; Chemokine CCL2 - genetics; Chemokines; Chromatography; Diabetes; diabetes mellitus; Diet; Donors; Endocrinology and Diabetes; Endokrinologi och diabetes; Energy expenditure; Energy Metabolism; Fatty acids; Fatty Acids, Volatile - analysis; Fecal Microbiota Transplantation; Feces; Feces - chemistry; Gastric Bypass; Gastroenterologi och hepatologi; Gastroenterology and Hepatology; Gastrointestinal Microbiome; Gastrointestinal surgery; Gastrointestinal Transit; Gene Expression; Germfree; Glucose; Glucose - metabolism; Glycerol; Gut Microbiota; Homeostasis; Humans; Inflammation; Insulin; Insulin Resistance; intestinal microbiology; Intestinal microflora; Intestinal transit time; Intestine; Lipolysis; Male; Metabolic syndrome; Metabolic Syndrome - metabolism; Metabolic Syndrome - physiopathology; Metabolic Syndrome - therapy; Metabolites; Metabolomics; Microbiota; Middle Aged; Monocyte chemoattractant protein 1; Probiotics; Studies; Subcutaneous Fat - metabolism; Surgery; Tissue Donors; Transplantation; Transplants & implants; Weight control; Young Adult; Netherlands; intestinal microbiology; bile acid metabolism; diabetes mellitus; gastrointestinal transit

ObjectiveBariatric surgery improves glucose metabolism. Recent data suggest that faecal microbiota transplantation (FMT) using faeces from postbariatric surgery diet-induced obese mice in germ-free mice improves glucose metabolism and intestinal homeostasis. We here investigated whether allogenic FM...