Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro

• Published in: Gut Vol. 13; no. 4; pp. 251 - 256
• Main Authors: Giannella, R. A., Broitman, S. A., Zamcheck, N.
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.04.1972; BMJ Publishing Group LTD
• Subjects: Achlorhydria - microbiology; Adult; Aged; Anemia, Pernicious - microbiology; Bacteria - drug effects; Culture Media; Female; Gastric Juice; Humans; Hydrochloric Acid - pharmacology; Hydrogen-Ion Concentration; Male; Middle Aged; Salmonella typhimurium - drug effects; Serratia marcescens - drug effects; Stomach - microbiology; Time Factors

Reassessment of the `gastric bactericidal barrier' to enteric bacteria in man included studies of the bactericidal activity of (1) the normal and achlorhydric stomach in vivo and (2) normal and achlorhydric gastric juice and other media in vitro. Within 30 minutes virtually all bacteria (Serrat...