Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition

• Published in: Annals of the rheumatic diseases Vol. 79; no. 1; pp. 132 - 140
• Main Authors: Yin, Jian, Sternes, Peter Richard, Wang, Mingbang, Song, Jing, Morrison, Mark, Li, Ting, Zhou, Ling, Wu, Xin, He, Fusheng, Zhu, Jian, Brown, Matthew A, Xu, Huji
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and European League Against Rheumatism 01.01.2020; Elsevier Limited
• Subjects: Adult; Ankylosing Spondylitis; Anti-TNF; Arthritis; Asian People; Bacteria; Case-Control Studies; China; Cross Reactions; Disease; Dysbacteriosis; Dysbiosis - immunology; Dysbiosis - microbiology; Epitopes; Epitopes - immunology; Female; Gastrointestinal Microbiome - genetics; Gastrointestinal Microbiome - immunology; Histocompatibility antigen HLA; HLA-B27 Antigen - immunology; Hospitals; Humans; Immune system; Inflammatory bowel disease; Intestinal microflora; Lymphocytes; Male; Metagenome; Metagenomics; Microbiomes; Microbiota; Middle Aged; Peptides; Peptides - immunology; Single-nucleotide polymorphism; Species; Spondylitis; Spondylitis, Ankylosing - drug therapy; Spondylitis, Ankylosing - immunology; Spondylitis, Ankylosing - microbiology; Spondyloarthritis; Studies; Taxonomy; TNF inhibitors; Tumor necrosis factor; Tumor Necrosis Factor Inhibitors - therapeutic use; Tumors; Young Adult; China; Beijing China; Ankylosing Spondylitis; Anti-TNF; Spondyloarthritis

ObjectivesDiverse evidence including clinical, genetic and microbiome studies support a major role of the gut microbiome in the common immune-mediated arthropathy, ankylosing spondylitis (AS). We set out to (1) further define the key microbial characteristics driving disease, and (2) examine the eff...