Relation between humoral responses to HIV gag and env proteins at seroconversion and clinical outcome of HIV infection

• Published in: BMJ Vol. 302; no. 6767; pp. 23 - 26
• Main Authors: Cheingsong-Popov, R, Panagiotidi, C, Bowcock, S, Aronstam, A, Wadsworth, J, Weber, J
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 05.01.1991; British Medical Association; BMJ Publishing Group LTD
• Subjects: AIDS; AIDS/HIV; Antibodies; Antibody formation; Antigens; Clinical outcomes; Disease progression; Gene Products, gag - immunology; Gene Products, nef - immunology; Health outcomes; Hemophilia A - immunology; HIV; HIV 1; HIV Antibodies - biosynthesis; HIV Antigens - immunology; HIV Core Protein p24; HIV Envelope Protein gp120 - immunology; HIV infections; HIV Infections - mortality; HIV Seropositivity - immunology; HIV Seropositivity - mortality; HIV-1 - immunology; Humans; Infections; Longitudinal Studies; nef Gene Products, Human Immunodeficiency Virus; Retrospective Studies; Survival Analysis; Viral Core Proteins - immunology

OBJECTIVE--To study the contribution of the humoral response to HIV-I at seroconversion to disease outcome after 84 months. DESIGN--A retrospective longitudinal study. SETTING--Two haemophilia centres in the United Kingdom. PATIENTS--88 Haemophiliac patients infected with HIV-I for whom sera were av...