General Aspects of Two-Component Regulatory Circuits in Bacteria: Domains, Signals and Roles

• Published in: Current protein & peptide science Vol. 18; no. 10; p. 990
• Main Authors: Padilla-Vaca, Felipe, Mondragón-Jaimes, Verónica, Franco, Bernardo
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2017
• Subjects: Bacteria - genetics; Bacteria - metabolism; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Gene Expression Regulation, Bacterial; Gene Regulatory Networks; Hydrogen-Ion Concentration; Light; Membrane Proteins - genetics; Membrane Proteins - metabolism; Oxidation-Reduction; Protein Domains; Quorum Sensing - genetics; Signal Transduction; Trans-Activators - genetics; Trans-Activators - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Virulence Factors - genetics; Virulence Factors - metabolism; gram-negative bacteria; virulence-related factors and determinants; effector functions; Two-component systems; signal transduction; environmental signals

All living organisms are subject to changing environments, which must be sensed in order to respond swiftly and efficiently. Two-component systems (TCS) are signal transduction regulatory circuits based typically on a membrane bound sensor kinase and a cytoplasmic response regulator, that is activat...