Neurologic Physiology after Removal of Therapy (NeuPaRT) study: study protocol of a multicentre, prospective, observational, pilot feasibility study of neurophysiology after withdrawal of life-sustaining measures

• Published in: BMJ open Vol. 13; no. 4; p. e073643
• Main Authors: Gofton, Teneille, Dhanani, Sonny, Meade, Maureen, Boyd, John Gordon, Chamberlain, Erika, Chandler, Jennifer, Chassé, Michaël, Scales, Nathan B, Choi, Yun-Hee, D'Aragon, Frédérick, Debicki, Derek, English, Shane, Fantaneanu, Tadeu A, Kramer, Andreas H, Kromm, Julie, Murphy, Nicholas, Norton, Loretta, Singh, Jeffrey, Smith, Maxwell J, Weijer, Charles, Shemie, Sam, Bentall, Tracey C, Campbell, Eileen, Slessarev, Marat
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 27.04.2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Protocol
• Subjects: Adult; adult intensive & critical care; Blood & organ donations; Brain research; Cohort Studies; Consciousness; Consent; Electroencephalography; Feasibility Studies; Flow velocity; Health sciences; Heart Arrest; Hemodynamics; Humans; Intensive Care; Intensive Care Units; Multicenter Studies as Topic; neurology; Neurophysiology; Observational Studies as Topic; Patients; Prospective Studies; Veins & arteries; neurophysiology; adult intensive & critical care; neurology

IntroductionIn donation after circulatory determination of death, death is declared 5 min after circulatory arrest. This practice assumes, but does not explicitly confirm, permanent loss of brain activity. While this assumption is rooted a strong physiological rationale, paucity of direct human data...