METRIC-EF: magnetic resonance enterography to predict disabling disease in newly diagnosed Crohn’s disease—protocol for a multicentre, non-randomised, single-arm, prospective study
IntroductionCrohn’s disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to suppress inflammation aims to prevent future complications such as stricturing or penetrating disease, and subsequent surgical resection. Therapeuti...
Saved in:
| Published in | BMJ open Vol. 12; no. 10; p. e067265 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
British Medical Journal Publishing Group
03.10.2022
BMJ Publishing Group LTD BMJ Publishing Group |
| Series | Protocol |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2044-6055 2044-6055 |
| DOI | 10.1136/bmjopen-2022-067265 |
Cover
Loading…
| Abstract | IntroductionCrohn’s disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to suppress inflammation aims to prevent future complications such as stricturing or penetrating disease, and subsequent surgical resection. Therapeutics are effective but associated with certain side-effects and relatively expensive. There is therefore an urgent need for robust methods to predict which newly diagnosed patients will develop disabling disease, to identify patients who are most likely to benefit from early, advanced therapies. We aim to determine if magnetic resonance enterography (MRE) features at diagnosis improve prediction of disabling CD within 5 years of diagnosis.Methods and analysisWe describe the protocol for a multicentre, non-randomised, single-arm, prospective study of adult patients with newly diagnosed CD. We will use patients already recruited to the METRIC study and extend their clinical follow-up, as well as a separate group of newly diagnosed patients who were not part of the METRIC trial (MRE within 3 months of diagnosis), to ensure an adequate sample size. Follow-up will extend for at least 4 years. The primary outcome is to evaluate the comparative predictive ability of prognostic models incorporating MRE severity scores (Magnetic resonance Enterography Global Score (MEGS), simplified MAgnetic Resonance Index of Activity (sMaRIA) and Lémann Index) versus models using standard characteristics alone to predict disabling CD (modified Beaugerie definition) within 5 years of new diagnosis.Ethics and disseminationThis study protocol achieved National Health Service Research Ethics Committee (NHS REC), London—Hampstead Research Ethics Committee approval (IRAS 217422). Our findings will be disseminated via conference presentations and peer-reviewed publications.Trial registration numberISRCTN76899103. |
|---|---|
| AbstractList | IntroductionCrohn’s disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to suppress inflammation aims to prevent future complications such as stricturing or penetrating disease, and subsequent surgical resection. Therapeutics are effective but associated with certain side-effects and relatively expensive. There is therefore an urgent need for robust methods to predict which newly diagnosed patients will develop disabling disease, to identify patients who are most likely to benefit from early, advanced therapies. We aim to determine if magnetic resonance enterography (MRE) features at diagnosis improve prediction of disabling CD within 5 years of diagnosis.Methods and analysisWe describe the protocol for a multicentre, non-randomised, single-arm, prospective study of adult patients with newly diagnosed CD. We will use patients already recruited to the METRIC study and extend their clinical follow-up, as well as a separate group of newly diagnosed patients who were not part of the METRIC trial (MRE within 3 months of diagnosis), to ensure an adequate sample size. Follow-up will extend for at least 4 years. The primary outcome is to evaluate the comparative predictive ability of prognostic models incorporating MRE severity scores (Magnetic resonance Enterography Global Score (MEGS), simplified MAgnetic Resonance Index of Activity (sMaRIA) and Lémann Index) versus models using standard characteristics alone to predict disabling CD (modified Beaugerie definition) within 5 years of new diagnosis.Ethics and disseminationThis study protocol achieved National Health Service Research Ethics Committee (NHS REC), London—Hampstead Research Ethics Committee approval (IRAS 217422). Our findings will be disseminated via conference presentations and peer-reviewed publications.Trial registration numberISRCTN76899103. Crohn's disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to suppress inflammation aims to prevent future complications such as stricturing or penetrating disease, and subsequent surgical resection. Therapeutics are effective but associated with certain side-effects and relatively expensive. There is therefore an urgent need for robust methods to predict which newly diagnosed patients will develop disabling disease, to identify patients who are most likely to benefit from early, advanced therapies. We aim to determine if magnetic resonance enterography (MRE) features at diagnosis improve prediction of disabling CD within 5 years of diagnosis. We describe the protocol for a multicentre, non-randomised, single-arm, prospective study of adult patients with newly diagnosed CD. We will use patients already recruited to the METRIC study and extend their clinical follow-up, as well as a separate group of newly diagnosed patients who were not part of the METRIC trial (MRE within 3 months of diagnosis), to ensure an adequate sample size. Follow-up will extend for at least 4 years. The primary outcome is to evaluate the comparative predictive ability of prognostic models incorporating MRE severity scores (Magnetic resonance Enterography Global Score (MEGS), simplified MAgnetic Resonance Index of Activity (sMaRIA) and Lémann Index) versus models using standard characteristics alone to predict disabling CD (modified Beaugerie definition) within 5 years of new diagnosis. This study protocol achieved National Health Service Research Ethics Committee (NHS REC), London-Hampstead Research Ethics Committee approval (IRAS 217422). Our findings will be disseminated via conference presentations and peer-reviewed publications. ISRCTN76899103. Introduction Crohn’s disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to suppress inflammation aims to prevent future complications such as stricturing or penetrating disease, and subsequent surgical resection. Therapeutics are effective but associated with certain side-effects and relatively expensive. There is therefore an urgent need for robust methods to predict which newly diagnosed patients will develop disabling disease, to identify patients who are most likely to benefit from early, advanced therapies. We aim to determine if magnetic resonance enterography (MRE) features at diagnosis improve prediction of disabling CD within 5 years of diagnosis.Methods and analysis We describe the protocol for a multicentre, non-randomised, single-arm, prospective study of adult patients with newly diagnosed CD. We will use patients already recruited to the METRIC study and extend their clinical follow-up, as well as a separate group of newly diagnosed patients who were not part of the METRIC trial (MRE within 3 months of diagnosis), to ensure an adequate sample size. Follow-up will extend for at least 4 years. The primary outcome is to evaluate the comparative predictive ability of prognostic models incorporating MRE severity scores (Magnetic resonance Enterography Global Score (MEGS), simplified MAgnetic Resonance Index of Activity (sMaRIA) and Lémann Index) versus models using standard characteristics alone to predict disabling CD (modified Beaugerie definition) within 5 years of new diagnosis.Ethics and dissemination This study protocol achieved National Health Service Research Ethics Committee (NHS REC), London—Hampstead Research Ethics Committee approval (IRAS 217422). Our findings will be disseminated via conference presentations and peer-reviewed publications.Trial registration number ISRCTN76899103. Crohn's disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to suppress inflammation aims to prevent future complications such as stricturing or penetrating disease, and subsequent surgical resection. Therapeutics are effective but associated with certain side-effects and relatively expensive. There is therefore an urgent need for robust methods to predict which newly diagnosed patients will develop disabling disease, to identify patients who are most likely to benefit from early, advanced therapies. We aim to determine if magnetic resonance enterography (MRE) features at diagnosis improve prediction of disabling CD within 5 years of diagnosis.INTRODUCTIONCrohn's disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to suppress inflammation aims to prevent future complications such as stricturing or penetrating disease, and subsequent surgical resection. Therapeutics are effective but associated with certain side-effects and relatively expensive. There is therefore an urgent need for robust methods to predict which newly diagnosed patients will develop disabling disease, to identify patients who are most likely to benefit from early, advanced therapies. We aim to determine if magnetic resonance enterography (MRE) features at diagnosis improve prediction of disabling CD within 5 years of diagnosis.We describe the protocol for a multicentre, non-randomised, single-arm, prospective study of adult patients with newly diagnosed CD. We will use patients already recruited to the METRIC study and extend their clinical follow-up, as well as a separate group of newly diagnosed patients who were not part of the METRIC trial (MRE within 3 months of diagnosis), to ensure an adequate sample size. Follow-up will extend for at least 4 years. The primary outcome is to evaluate the comparative predictive ability of prognostic models incorporating MRE severity scores (Magnetic resonance Enterography Global Score (MEGS), simplified MAgnetic Resonance Index of Activity (sMaRIA) and Lémann Index) versus models using standard characteristics alone to predict disabling CD (modified Beaugerie definition) within 5 years of new diagnosis.METHODS AND ANALYSISWe describe the protocol for a multicentre, non-randomised, single-arm, prospective study of adult patients with newly diagnosed CD. We will use patients already recruited to the METRIC study and extend their clinical follow-up, as well as a separate group of newly diagnosed patients who were not part of the METRIC trial (MRE within 3 months of diagnosis), to ensure an adequate sample size. Follow-up will extend for at least 4 years. The primary outcome is to evaluate the comparative predictive ability of prognostic models incorporating MRE severity scores (Magnetic resonance Enterography Global Score (MEGS), simplified MAgnetic Resonance Index of Activity (sMaRIA) and Lémann Index) versus models using standard characteristics alone to predict disabling CD (modified Beaugerie definition) within 5 years of new diagnosis.This study protocol achieved National Health Service Research Ethics Committee (NHS REC), London-Hampstead Research Ethics Committee approval (IRAS 217422). Our findings will be disseminated via conference presentations and peer-reviewed publications.ETHICS AND DISSEMINATIONThis study protocol achieved National Health Service Research Ethics Committee (NHS REC), London-Hampstead Research Ethics Committee approval (IRAS 217422). Our findings will be disseminated via conference presentations and peer-reviewed publications.ISRCTN76899103.TRIAL REGISTRATION NUMBERISRCTN76899103. |
| Author | Travis, Simon Taylor, Stuart Andrew Plumb, Andrew Vega, Roser Halligan, Steve Bloom, Stuart Hart, Ailsa L Mallett, Sue Clarke, Caroline S Jacobs, Ilan Kumar, Shankar Hamlin, John Bhatnagar, Gauraang |
| AuthorAffiliation | 3 Research Department of Primary Care and Population Health , University College London , London , UK 4 Department of Gastroenterology , Leeds Teaching Hospitals NHS Trust , Leeds , UK 5 Inflammatory Bowel Disease Unit , St Mark's Hospital and Academic Institute , London , UK 7 Kennedy Institute and Translational Gastroenterology Unit , University of Oxford and Biomedical Research Centre , Oxford , UK 1 Centre for Medical Imaging , University College London , London , UK 2 Department of Gastroenterology , University College London Hospitals NHS Foundation Trust , London , UK 6 Citibank , London , UK |
| AuthorAffiliation_xml | – name: 6 Citibank , London , UK – name: 1 Centre for Medical Imaging , University College London , London , UK – name: 2 Department of Gastroenterology , University College London Hospitals NHS Foundation Trust , London , UK – name: 4 Department of Gastroenterology , Leeds Teaching Hospitals NHS Trust , Leeds , UK – name: 7 Kennedy Institute and Translational Gastroenterology Unit , University of Oxford and Biomedical Research Centre , Oxford , UK – name: 3 Research Department of Primary Care and Population Health , University College London , London , UK – name: 5 Inflammatory Bowel Disease Unit , St Mark's Hospital and Academic Institute , London , UK |
| Author_xml | – sequence: 1 givenname: Shankar orcidid: 0000-0002-5945-8791 surname: Kumar fullname: Kumar, Shankar organization: Centre for Medical Imaging, University College London, London, UK – sequence: 2 givenname: Andrew surname: Plumb fullname: Plumb, Andrew organization: Centre for Medical Imaging, University College London, London, UK – sequence: 3 givenname: Sue orcidid: 0000-0002-0596-8200 surname: Mallett fullname: Mallett, Sue organization: Centre for Medical Imaging, University College London, London, UK – sequence: 4 givenname: Gauraang surname: Bhatnagar fullname: Bhatnagar, Gauraang organization: Centre for Medical Imaging, University College London, London, UK – sequence: 5 givenname: Stuart surname: Bloom fullname: Bloom, Stuart organization: Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK – sequence: 6 givenname: Caroline S orcidid: 0000-0002-4676-1257 surname: Clarke fullname: Clarke, Caroline S organization: Research Department of Primary Care and Population Health, University College London, London, UK – sequence: 7 givenname: John surname: Hamlin fullname: Hamlin, John organization: Department of Gastroenterology, Leeds Teaching Hospitals NHS Trust, Leeds, UK – sequence: 8 givenname: Ailsa L surname: Hart fullname: Hart, Ailsa L organization: Inflammatory Bowel Disease Unit, St Mark's Hospital and Academic Institute, London, UK – sequence: 9 givenname: Ilan surname: Jacobs fullname: Jacobs, Ilan organization: Citibank, London, UK – sequence: 10 givenname: Simon surname: Travis fullname: Travis, Simon organization: Kennedy Institute and Translational Gastroenterology Unit, University of Oxford and Biomedical Research Centre, Oxford, UK – sequence: 11 givenname: Roser surname: Vega fullname: Vega, Roser organization: Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK – sequence: 12 givenname: Steve orcidid: 0000-0003-0632-5108 surname: Halligan fullname: Halligan, Steve organization: Centre for Medical Imaging, University College London, London, UK – sequence: 13 givenname: Stuart Andrew orcidid: 0000-0002-6765-8806 surname: Taylor fullname: Taylor, Stuart Andrew email: stuart.taylor@ucl.ac.uk organization: Centre for Medical Imaging, University College London, London, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36192092$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9UstuEzEUHaEiWkq_AAlZYsMiQ_0Ye2ZYVEJRCpGKkFBZWx77Tupoxh7sSVF2_Qg2_Anf0y_BaRJou-jd-Mo-59yHz8vswHkHWfaa4PeEMHHa9Es_gMsppjTHoqSCP8uOKC6KXGDOD-7lh9lJjEucouA15_RFdsgEqSmu6VH258vs8tt8ms_OP6BeLRyMVqMA0TvlNCBwIwS_CGq4WqPRoyGAsXpExkbVdNYtNhmoCMg65OBnt04XScZHMGga_JW7vfkd96Dbm19D8KPXvkOtD0ihftWlgqlKgAlKI-ZBOeP7BDcTFJN-B7kK_SQV9nEAPdprQHFcmfWr7Hmruggnu_M4-34-u5x-zi--fppPP17kDWf1mJtWcFw0nOAaREVaAVXLylJT4C0tOVFVQmBoWspLVheibrnmZasFrSuuMWPH2Xyra7xayiHYXoW19MrKuwsfFlKFNEMHEgMmVVU01LS0SFERU6UlU0w0JkybpHW21RpWTQ_mbm7VPRB9-OLslVz4a1lzxgmnSeDdTiD4HyuIo0yr0tB1yoFfRUlLSqjAhBcJ-vYRdOlXwaVVJRQrRFExUibUm_sd_Wtlb5AEqLcAnT4gBmiltqMard80aDtJsNz4Ue78KDd-lFs_Ji57xN3LP8063bLS4_-en2L8BcUk-Rc |
| CitedBy_id | crossref_primary_10_1177_17562848231151293 crossref_primary_10_1093_ecco_jcc_jjae042 crossref_primary_10_1080_17474124_2023_2274926 crossref_primary_10_1177_17562848231173331 |
| Cites_doi | 10.1259/bjr.20210995 10.1016/j.crohns.2009.12.002 10.1053/j.gastro.2005.12.019 10.1111/jgh.12724 10.1016/S0140-6736(08)60304-9 10.1136/gutjnl-2014-308101 10.1016/j.clinre.2022.101974 10.1007/s00261-022-03624-z 10.1136/gutjnl-2012-303376 10.1053/j.gastro.2019.03.051 10.1046/j.1365-2036.2000.00886.x 10.1016/j.crad.2019.03.013 10.1136/gut.2005.082909 10.1007/s00535-016-1253-6 10.1016/j.cgh.2022.01.055 10.1007/s00330-013-3010-z 10.1093/ecco-jcc/jjw168 10.1136/gutjnl-2021-326562 10.3748/wjg.v19.i24.3866 10.1038/nrgastro.2013.31 10.1093/ibd/izaa025 10.1016/0895-4356(95)00048-8 10.1093/ibd/izac140 10.1002/sim.9025 10.1136/bmj.e7586 10.1016/j.gastro.2003.08.025 10.3310/hta25450 10.1136/gutjnl-2019-318484 10.1016/S0140-6736(15)00068-9 10.1053/j.gastro.2014.09.015 10.1136/gut.2010.224154 10.1016/j.jclinepi.2004.06.017 10.1056/NEJMoa0904492 10.1007/s00330-015-4036-1 10.1093/ecco-jcc/jjab180 10.1002/sim.4067 10.1016/S0140-6736(16)31711-1 10.1093/ecco-jcc/jjac062 10.1093/ecco-jcc/jjw185 10.1080/00365520801957149 10.1016/S0140-6736(17)32641-7 10.1186/1471-230X-14-142 10.1093/ecco-jcc/jjaa030 10.1016/S2468-1253(18)30161-4 10.1093/ecco-jcc/jjx156 |
| ContentType | Journal Article |
| Copyright | Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. 2022 Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. 2022 |
| Copyright_xml | – notice: Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. – notice: 2022 Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. 2022 |
| DBID | 9YT ACMMV AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7RV 7X7 7XB 88E 88G 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR BTHHO CCPQU COVID DWQXO FYUFA GHDGH GNUQQ K9- K9. KB0 M0R M0S M1P M2M NAPCQ PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM DOA |
| DOI | 10.1136/bmjopen-2022-067265 |
| DatabaseName | BMJ Open Access Journals (WRLC) BMJ Journals:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central BMJ Journals ProQuest One Coronavirus Research Database ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Consumer Health Database (Alumni Edition) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Consumer Health Database ProQuest Health & Medical Collection Medical Database Psychology Database Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ, Directory of open access journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Family Health (Alumni Edition) ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest Family Health ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition BMJ Journals ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Publicly Available Content Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: ACMMV name: BMJ Journals:Open Access url: https://journals.bmj.com/ sourceTypes: Publisher – sequence: 5 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2044-6055 |
| ExternalDocumentID | oai_doaj_org_article_0e01884b2df2444481d8092201c013cd PMC9535152 36192092 10_1136_bmjopen_2022_067265 bmjopen |
| Genre | Clinical Trial Protocol Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | England Scotland United Kingdom--UK United States--US |
| GeographicLocations_xml | – name: England – name: United Kingdom--UK – name: United States--US – name: Scotland |
| GrantInformation_xml | – fundername: National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme grantid: project number 15/59/17 – fundername: Wellcome Trust – fundername: Department of Health – fundername: ; grantid: project number 15/59/17 |
| GroupedDBID | --- 4.4 53G 5VS 7RV 7X7 7~R 88E 8FI 8FJ 9YT ABUWG ACGFS ACMMV ADBBV AENEX AFKRA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BCNDV BENPR BKNYI BPHCQ BTFSW BTHHO CCPQU DIK DWQXO EBS FYUFA GNUQQ GROUPED_DOAJ GX1 H13 HMCUK HYE HZ~ K9- KQ8 M0R M1P M2M M48 M~E NAPCQ O9- OK1 PGMZT PHGZT PIMPY PQQKQ PROAC PSQYO PSYQQ RHI RMJ RPM UKHRP AAYXX ADRAZ BVXVI CITATION EJD PHGZM CGR CUY CVF ECM EIF NPM PJZUB PPXIY 3V. 7XB 8FK COVID K9. PKEHL PQEST PQUKI PRINS PUEGO Q9U 7X8 5PM |
| ID | FETCH-LOGICAL-b539t-df6504b5109e681f6e8f377c2e5f2751a8df60ebf25739469f5c57fc62985c033 |
| IEDL.DBID | DOA |
| ISSN | 2044-6055 |
| IngestDate | Wed Aug 27 01:32:08 EDT 2025 Thu Aug 21 18:39:51 EDT 2025 Fri Jul 11 11:10:10 EDT 2025 Fri Aug 29 18:19:16 EDT 2025 Mon Jul 21 06:02:55 EDT 2025 Thu Apr 24 23:11:12 EDT 2025 Tue Jul 01 02:45:10 EDT 2025 Thu Apr 24 23:02:17 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | Inflammatory bowel disease Adult gastroenterology RADIOLOGY & IMAGING Magnetic resonance imaging Gastrointestinal imaging |
| Language | English |
| License | This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-b539t-df6504b5109e681f6e8f377c2e5f2751a8df60ebf25739469f5c57fc62985c033 |
| Notes | Protocol ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Undefined-1 content type line 23 |
| ORCID | 0000-0002-4676-1257 0000-0002-5945-8791 0000-0002-0596-8200 0000-0002-6765-8806 0000-0003-0632-5108 |
| OpenAccessLink | https://doaj.org/article/0e01884b2df2444481d8092201c013cd |
| PMID | 36192092 |
| PQID | 2734648317 |
| PQPubID | 2040975 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_0e01884b2df2444481d8092201c013cd pubmedcentral_primary_oai_pubmedcentral_nih_gov_9535152 proquest_miscellaneous_2721260154 proquest_journals_2734648317 pubmed_primary_36192092 crossref_citationtrail_10_1136_bmjopen_2022_067265 crossref_primary_10_1136_bmjopen_2022_067265 bmj_journals_10_1136_bmjopen_2022_067265 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-10-03 |
| PublicationDateYYYYMMDD | 2022-10-03 |
| PublicationDate_xml | – month: 10 year: 2022 text: 2022-10-03 day: 03 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London – name: BMA House, Tavistock Square, London, WC1H 9JR |
| PublicationSeriesTitle | Protocol |
| PublicationTitle | BMJ open |
| PublicationTitleAbbrev | BMJ Open |
| PublicationTitleAlternate | BMJ Open |
| PublicationYear | 2022 |
| Publisher | British Medical Journal Publishing Group BMJ Publishing Group LTD BMJ Publishing Group |
| Publisher_xml | – name: British Medical Journal Publishing Group – name: BMJ Publishing Group LTD – name: BMJ Publishing Group |
| References | Kumar, Hakim, Alexakis (R7) 2015; 30 Satsangi, Silverberg, Vermeire (R39) 2006; 55 Sandborn, Fazio, Feagan (R40) 2003; 125 Halligan, Boone, Archer (R25) 2021; 25 Loly, Belaiche, Louis (R37) 2008; 43 Taylor, Mallett, Bhatnagar (R15) 2018; 3 Dignass, Van Assche, Lindsay (R17) 2010; 4 Jauregui-Amezaga, Rimola, Ordás (R26) 2015; 64 Makanyanga, Pendsé, Dikaios (R31) 2014; 24 Peyrin-Biroulet, Fiorino, Buisson (R3) 2013; 10 Peduzzi, Concato, Feinstein (R42) 1995; 48 Fiorino, Morin, Bonovas (R27) 2017; 11 Rabilloud, Bajeux, Siproudhis (R36) 2022; 46 Rao, Kumar, Taylor (R6) 2019; 74 Dias, Rodrigues, da Costa-Pereira (R35) 2013; 19 Beaugerie, Seksik, Nion-Larmurier (R38) 2006; 130 Capozzi, Ordás, Fernandez-Clotet (R11) 2020; 14 Ordás, Rimola, Alfaro (R12) 2019; 157 Taylor, Mallett, Bhatnagar (R28) 2014; 14 Kumar, Pollok, Goldsmith (R24) 2022 Khanna, Bressler, Levesque (R23) 2015; 386 Klang, Amitai, Lahat (R32) 2017 Kucharzik, Tielbeek, Carter (R16) 2022; 16 Prezzi, Bhatnagar, Vega (R30) 2016; 26 Pariente, Mary, Danese (R34) 2015; 148 Dane, Qian, Krieger (R45) 2022 D'Haens, Baert, van Assche (R19) 2008; 371 Bhatnagar, Mallett, Quinn (R13) 2022; 95 Vergouwe, Steyerberg, Eijkemans (R41) 2005; 58 White, Royston, Wood (R44) 2011; 30 Rubin, Hungin, Kelly (R4) 2000; 14 Gomollón, Dignass, Annese (R9) 2017; 11 Hanžel, Jairath, Ma (R10) 2022 Colombel, Sandborn, Reinisch (R18) 2010; 362 Rimola, Alvarez-Cofiño, Pérez-Jeldres (R33) 2017; 52 Lamb, Kennedy, Raine (R2) 2019; 68 Rimola, Torres, Kumar (R14) 2022 Kumar, Parry, Mallett (R8) 2022; 389 Mowat, Cole, Windsor (R5) 2011; 60 Riley, Debray, Collins (R43) 2021; 40 Chan, Tetzlaff, Gøtzsche (R29) 2013; 346 Torres, Mehandru, Colombel (R1) 2017; 389 Reinisch, Panaccione, Bossuyt (R21) 2020; 26 Colombel, Panaccione, Bossuyt (R20) 2017; 390 van der Valk, Mangen, Leenders (R22) 2014; 63 Rimola (2022100307301820000_12.10.e067265.14) 2022 Capozzi (2022100307301820000_12.10.e067265.11) 2020; 14 Bhatnagar (2022100307301820000_12.10.e067265.13) 2022; 95 Rao (2022100307301820000_12.10.e067265.6) 2019; 74 Torres (2022100307301820000_12.10.e067265.1) 2017; 389 2022100307301820000_12.10.e067265.29 2022100307301820000_12.10.e067265.28 Makanyanga (2022100307301820000_12.10.e067265.31) 2014; 24 2022100307301820000_12.10.e067265.22 2022100307301820000_12.10.e067265.44 2022100307301820000_12.10.e067265.43 Kucharzik (2022100307301820000_12.10.e067265.16) 2022; 16 2022100307301820000_12.10.e067265.20 2022100307301820000_12.10.e067265.42 2022100307301820000_12.10.e067265.41 2022100307301820000_12.10.e067265.26 Prezzi (2022100307301820000_12.10.e067265.30) 2016; 26 2022100307301820000_12.10.e067265.23 Rabilloud (2022100307301820000_12.10.e067265.36) 2022; 46 Halligan (2022100307301820000_12.10.e067265.25) 2021; 25 2022100307301820000_12.10.e067265.40 Hanžel (2022100307301820000_12.10.e067265.10) 2022 Reinisch (2022100307301820000_12.10.e067265.21) 2020; 26 2022100307301820000_12.10.e067265.2 2022100307301820000_12.10.e067265.4 2022100307301820000_12.10.e067265.19 Kumar (2022100307301820000_12.10.e067265.24) 2022 Fiorino (2022100307301820000_12.10.e067265.27) 2017; 11 2022100307301820000_12.10.e067265.3 2022100307301820000_12.10.e067265.18 Dane (2022100307301820000_12.10.e067265.45) 2022 2022100307301820000_12.10.e067265.17 2022100307301820000_12.10.e067265.39 2022100307301820000_12.10.e067265.5 2022100307301820000_12.10.e067265.38 Kumar (2022100307301820000_12.10.e067265.7) 2015; 30 2022100307301820000_12.10.e067265.8 Taylor (2022100307301820000_12.10.e067265.15) 2018; 3 2022100307301820000_12.10.e067265.9 2022100307301820000_12.10.e067265.32 2022100307301820000_12.10.e067265.37 2022100307301820000_12.10.e067265.35 2022100307301820000_12.10.e067265.12 Rimola (2022100307301820000_12.10.e067265.33) 2017; 52 2022100307301820000_12.10.e067265.34 |
| References_xml | – volume: 95 year: 2022 ident: R13 article-title: Interobserver variation in the interpretation of magnetic resonance enterography in Crohn's disease publication-title: Br J Radiol doi: 10.1259/bjr.20210995 – volume: 4 start-page: 28 year: 2010 ident: R17 article-title: The second European evidence-based consensus on the diagnosis and management of crohn's disease: current management publication-title: J Crohns Colitis doi: 10.1016/j.crohns.2009.12.002 – volume: 130 start-page: 650 year: 2006 ident: R38 article-title: Predictors of crohn's disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2005.12.019 – volume: 30 start-page: 86 year: 2015 ident: R7 article-title: Small intestinal contrast ultrasonography for the detection of small bowel complications in Crohn's disease: correlation with intraoperative findings and magnetic resonance enterography publication-title: J Gastroenterol Hepatol doi: 10.1111/jgh.12724 – volume: 371 start-page: 660 year: 2008 ident: R19 article-title: Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial publication-title: Lancet doi: 10.1016/S0140-6736(08)60304-9 – volume: 64 start-page: 1397 year: 2015 ident: R26 article-title: Value of endoscopy and MRI for predicting intestinal surgery in patients with crohn's disease in the era of biologics publication-title: Gut doi: 10.1136/gutjnl-2014-308101 – volume: 46 year: 2022 ident: R36 article-title: Long-term outcomes and predictors of disabling disease in a population-based cohort of patients with incident crohn's disease diagnosed between 1994 and 1997 publication-title: Clin Res Hepatol Gastroenterol doi: 10.1016/j.clinre.2022.101974 – year: 2022 ident: R45 article-title: Correlation between imaging findings on outpatient MR enterography (MRE) in adult patients with crohn disease and progression to surgery within 5 years publication-title: Abdom Radiol doi: 10.1007/s00261-022-03624-z – volume: 63 start-page: 72 year: 2014 ident: R22 article-title: Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFα therapy: results from the coin study publication-title: Gut doi: 10.1136/gutjnl-2012-303376 – volume: 157 start-page: 432 year: 2019 ident: R12 article-title: Development and validation of a simplified magnetic resonance index of activity for crohn's disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2019.03.051 – volume: 14 start-page: 1553 year: 2000 ident: R4 article-title: Inflammatory bowel disease: epidemiology and management in an English general practice population publication-title: Aliment Pharmacol Ther doi: 10.1046/j.1365-2036.2000.00886.x – volume: 74 start-page: 578 year: 2019 ident: R6 article-title: Diagnostic pathways in crohn's disease publication-title: Clin Radiol doi: 10.1016/j.crad.2019.03.013 – volume: 55 start-page: 749 year: 2006 ident: R39 article-title: The montreal classification of inflammatory bowel disease: controversies, consensus, and implications publication-title: Gut doi: 10.1136/gut.2005.082909 – volume: 52 start-page: 585 year: 2017 ident: R33 article-title: Comparison of three magnetic resonance enterography indices for grading activity in crohn's disease publication-title: J Gastroenterol doi: 10.1007/s00535-016-1253-6 – year: 2022 ident: R10 article-title: Responsiveness of magnetic resonance enterography indices for evaluation of luminal disease activity in crohn's disease publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2022.01.055 – volume: 24 start-page: 277 year: 2014 ident: R31 article-title: Evaluation of crohn's disease activity: initial validation of a magnetic resonance enterography global score (MEGS) against faecal calprotectin publication-title: Eur Radiol doi: 10.1007/s00330-013-3010-z – volume: 11 start-page: 3 year: 2017 ident: R9 article-title: 3Rd European evidence-based consensus on the diagnosis and management of crohn's disease 2016: Part 1: diagnosis and medical management publication-title: J Crohns Colitis doi: 10.1093/ecco-jcc/jjw168 – year: 2022 ident: R14 article-title: Recent advances in clinical practice: advances in cross-sectional imaging in inflammatory bowel disease publication-title: Gut doi: 10.1136/gutjnl-2021-326562 – year: 2017 ident: R32 article-title: Capsule endoscopy validation of the magnetic enterography global score in patients with established cCrohn's disease publication-title: J Crohns Colitis doi: 10.3748/wjg.v19.i24.3866 – volume: 10 start-page: 345 year: 2013 ident: R3 article-title: First-line therapy in adult crohn's disease: who should receive anti-TNF agents? publication-title: Nat Rev Gastroenterol Hepatol doi: 10.1038/nrgastro.2013.31 – volume: 26 start-page: 1562 year: 2020 ident: R21 article-title: Association of biomarker cutoffs and endoscopic outcomes in crohn's disease: a post hoc analysis from the calm study publication-title: Inflamm Bowel Dis doi: 10.1093/ibd/izaa025 – volume: 48 start-page: 1503 year: 1995 ident: R42 article-title: Importance of events per independent variable in proportional hazards regression analysis. II. accuracy and precision of regression estimates publication-title: J Clin Epidemiol doi: 10.1016/0895-4356(95)00048-8 – year: 2022 ident: R24 article-title: Renal and urological disorders associated with inflammatory bowel disease publication-title: Inflamm Bowel Dis doi: 10.1093/ibd/izac140 – volume: 40 start-page: 4230 year: 2021 ident: R43 article-title: Minimum sample size for external validation of a clinical prediction model with a binary outcome publication-title: Stat Med doi: 10.1002/sim.9025 – volume: 19 start-page: 3866 year: 2013 ident: R35 article-title: Clinical prognostic factors for disabling crohn's disease: a systematic review and meta-analysis publication-title: World J Gastroenterol doi: 10.3748/wjg.v19.i24.3866 – volume: 346 year: 2013 ident: R29 article-title: Spirit 2013 explanation and elaboration: guidance for protocols of clinical trials publication-title: BMJ doi: 10.1136/bmj.e7586 – volume: 125 start-page: 1508 year: 2003 ident: R40 article-title: AGA technical review on perianal crohn's disease publication-title: Gastroenterology doi: 10.1016/j.gastro.2003.08.025 – volume: 25 start-page: 1 year: 2021 ident: R25 article-title: Prognostic biomarkers to identify patients likely to develop severe crohn’s disease: a systematic review publication-title: Health Technol Assess doi: 10.3310/hta25450 – volume: 68 start-page: s1 year: 2019 ident: R2 article-title: British society of gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults publication-title: Gut doi: 10.1136/gutjnl-2019-318484 – volume: 386 start-page: 1825 year: 2015 ident: R23 article-title: Early combined immunosuppression for the management of crohn's disease (react): a cluster randomised controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(15)00068-9 – volume: 148 start-page: 52 year: 2015 ident: R34 article-title: Development of the Lémann index to assess digestive tract damage in patients with crohn's disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2014.09.015 – volume: 60 start-page: 571 year: 2011 ident: R5 article-title: Guidelines for the management of inflammatory bowel disease in adults publication-title: Gut doi: 10.1136/gut.2010.224154 – volume: 58 start-page: 475 year: 2005 ident: R41 article-title: Substantial effective sample sizes were required for external validation studies of predictive logistic regression models publication-title: J Clin Epidemiol doi: 10.1016/j.jclinepi.2004.06.017 – volume: 362 start-page: 1383 year: 2010 ident: R18 article-title: Infliximab, azathioprine, or combination therapy for crohn's disease publication-title: N Engl J Med doi: 10.1056/NEJMoa0904492 – volume: 26 start-page: 2107 year: 2016 ident: R30 article-title: Monitoring crohn's disease during anti-TNF-α therapy: validation of the magnetic resonance enterography global score (MEGS) against a combined clinical reference standard publication-title: Eur Radiol doi: 10.1007/s00330-015-4036-1 – volume: 16 start-page: 523 year: 2022 ident: R16 article-title: ECCO-ESGAR topical review on optimizing reporting for cross-sectional imaging in inflammatory bowel disease publication-title: J Crohns Colitis doi: 10.1093/ecco-jcc/jjab180 – volume: 30 start-page: 377 year: 2011 ident: R44 article-title: Multiple imputation using chained equations: issues and guidance for practice publication-title: Stat Med doi: 10.1002/sim.4067 – volume: 389 start-page: 1741 year: 2017 ident: R1 article-title: Crohn’s disease publication-title: The Lancet doi: 10.1016/S0140-6736(16)31711-1 – volume: 389 year: 2022 ident: R8 article-title: Diagnostic performance of magnetic resonance enterography disease activity indices compared with a histological reference standard for adult terminal ileal crohn’s disease: experience from the METRIC trial publication-title: Journal of Crohn's and Colitis doi: 10.1093/ecco-jcc/jjac062 – volume: 11 start-page: 274 year: 2017 ident: R27 article-title: Prevalence of bowel damage assessed by cross-sectional imaging in early crohn's disease and its impact on disease outcome publication-title: J Crohns Colitis doi: 10.1093/ecco-jcc/jjw185 – volume: 43 start-page: 948 year: 2008 ident: R37 article-title: Predictors of severe crohn's disease publication-title: Scand J Gastroenterol doi: 10.1080/00365520801957149 – volume: 390 start-page: 2779 year: 2017 ident: R20 article-title: Effect of tight control management on Crohn's disease (calm): a multicentre, randomised, controlled phase 3 trial publication-title: Lancet doi: 10.1016/S0140-6736(17)32641-7 – volume: 14 year: 2014 ident: R28 article-title: Metric (MREnterography or ulTRasound in crohn's disease): a study protocol for a multicentre, non-randomised, single-arm, prospective comparison study of magnetic resonance enterography and small bowel ulTRasound compared to a reference standard in those aged 16 and over publication-title: BMC Gastroenterol doi: 10.1186/1471-230X-14-142 – volume: 14 start-page: 1074 year: 2020 ident: R11 article-title: Validation of the simplified magnetic resonance index of activity [sMARIA] without gadolinium-enhanced sequences for crohn's disease publication-title: J Crohns Colitis doi: 10.1093/ecco-jcc/jjaa030 – volume: 3 start-page: 548 year: 2018 ident: R15 article-title: Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed crohn's disease (metric): a multicentre trial publication-title: Lancet Gastroenterol Hepatol doi: 10.1016/S2468-1253(18)30161-4 – volume: 389 start-page: 1741 year: 2017 ident: 2022100307301820000_12.10.e067265.1 article-title: Crohn’s disease publication-title: The Lancet doi: 10.1016/S0140-6736(16)31711-1 – ident: 2022100307301820000_12.10.e067265.34 doi: 10.1053/j.gastro.2014.09.015 – volume: 30 start-page: 86 year: 2015 ident: 2022100307301820000_12.10.e067265.7 article-title: Small intestinal contrast ultrasonography for the detection of small bowel complications in Crohn's disease: correlation with intraoperative findings and magnetic resonance enterography publication-title: J Gastroenterol Hepatol doi: 10.1111/jgh.12724 – year: 2022 ident: 2022100307301820000_12.10.e067265.24 article-title: Renal and urological disorders associated with inflammatory bowel disease publication-title: Inflamm Bowel Dis doi: 10.1093/ibd/izac140 – ident: 2022100307301820000_12.10.e067265.20 doi: 10.1016/S0140-6736(17)32641-7 – ident: 2022100307301820000_12.10.e067265.5 doi: 10.1136/gut.2010.224154 – ident: 2022100307301820000_12.10.e067265.38 doi: 10.1053/j.gastro.2005.12.019 – ident: 2022100307301820000_12.10.e067265.17 doi: 10.1016/j.crohns.2009.12.002 – ident: 2022100307301820000_12.10.e067265.28 doi: 10.1186/1471-230X-14-142 – ident: 2022100307301820000_12.10.e067265.19 doi: 10.1016/S0140-6736(08)60304-9 – ident: 2022100307301820000_12.10.e067265.40 doi: 10.1016/j.gastro.2003.08.025 – ident: 2022100307301820000_12.10.e067265.18 doi: 10.1056/NEJMoa0904492 – volume: 52 start-page: 585 year: 2017 ident: 2022100307301820000_12.10.e067265.33 article-title: Comparison of three magnetic resonance enterography indices for grading activity in crohn's disease publication-title: J Gastroenterol doi: 10.1007/s00535-016-1253-6 – ident: 2022100307301820000_12.10.e067265.43 doi: 10.1002/sim.9025 – ident: 2022100307301820000_12.10.e067265.39 doi: 10.1136/gut.2005.082909 – volume: 74 start-page: 578 year: 2019 ident: 2022100307301820000_12.10.e067265.6 article-title: Diagnostic pathways in crohn's disease publication-title: Clin Radiol doi: 10.1016/j.crad.2019.03.013 – volume: 16 start-page: 523 year: 2022 ident: 2022100307301820000_12.10.e067265.16 article-title: ECCO-ESGAR topical review on optimizing reporting for cross-sectional imaging in inflammatory bowel disease publication-title: J Crohns Colitis doi: 10.1093/ecco-jcc/jjab180 – volume: 26 start-page: 2107 year: 2016 ident: 2022100307301820000_12.10.e067265.30 article-title: Monitoring crohn's disease during anti-TNF-α therapy: validation of the magnetic resonance enterography global score (MEGS) against a combined clinical reference standard publication-title: Eur Radiol doi: 10.1007/s00330-015-4036-1 – ident: 2022100307301820000_12.10.e067265.4 doi: 10.1046/j.1365-2036.2000.00886.x – year: 2022 ident: 2022100307301820000_12.10.e067265.10 article-title: Responsiveness of magnetic resonance enterography indices for evaluation of luminal disease activity in crohn's disease publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2022.01.055 – volume: 14 start-page: 1074 year: 2020 ident: 2022100307301820000_12.10.e067265.11 article-title: Validation of the simplified magnetic resonance index of activity [sMARIA] without gadolinium-enhanced sequences for crohn's disease publication-title: J Crohns Colitis doi: 10.1093/ecco-jcc/jjaa030 – volume: 25 start-page: 1 year: 2021 ident: 2022100307301820000_12.10.e067265.25 article-title: Prognostic biomarkers to identify patients likely to develop severe crohn’s disease: a systematic review publication-title: Health Technol Assess doi: 10.3310/hta25450 – ident: 2022100307301820000_12.10.e067265.22 doi: 10.1136/gutjnl-2012-303376 – volume: 24 start-page: 277 year: 2014 ident: 2022100307301820000_12.10.e067265.31 article-title: Evaluation of crohn's disease activity: initial validation of a magnetic resonance enterography global score (MEGS) against faecal calprotectin publication-title: Eur Radiol doi: 10.1007/s00330-013-3010-z – ident: 2022100307301820000_12.10.e067265.44 doi: 10.1002/sim.4067 – volume: 95 year: 2022 ident: 2022100307301820000_12.10.e067265.13 article-title: Interobserver variation in the interpretation of magnetic resonance enterography in Crohn's disease publication-title: Br J Radiol doi: 10.1259/bjr.20210995 – ident: 2022100307301820000_12.10.e067265.26 doi: 10.1136/gutjnl-2014-308101 – ident: 2022100307301820000_12.10.e067265.37 doi: 10.1080/00365520801957149 – volume: 3 start-page: 548 year: 2018 ident: 2022100307301820000_12.10.e067265.15 article-title: Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed crohn's disease (metric): a multicentre trial publication-title: Lancet Gastroenterol Hepatol doi: 10.1016/S2468-1253(18)30161-4 – volume: 26 start-page: 1562 year: 2020 ident: 2022100307301820000_12.10.e067265.21 article-title: Association of biomarker cutoffs and endoscopic outcomes in crohn's disease: a post hoc analysis from the calm study publication-title: Inflamm Bowel Dis doi: 10.1093/ibd/izaa025 – volume: 46 year: 2022 ident: 2022100307301820000_12.10.e067265.36 article-title: Long-term outcomes and predictors of disabling disease in a population-based cohort of patients with incident crohn's disease diagnosed between 1994 and 1997 publication-title: Clin Res Hepatol Gastroenterol doi: 10.1016/j.clinre.2022.101974 – ident: 2022100307301820000_12.10.e067265.35 doi: 10.3748/wjg.v19.i24.3866 – year: 2022 ident: 2022100307301820000_12.10.e067265.45 article-title: Correlation between imaging findings on outpatient MR enterography (MRE) in adult patients with crohn disease and progression to surgery within 5 years publication-title: Abdom Radiol doi: 10.1007/s00261-022-03624-z – year: 2022 ident: 2022100307301820000_12.10.e067265.14 article-title: Recent advances in clinical practice: advances in cross-sectional imaging in inflammatory bowel disease publication-title: Gut doi: 10.1136/gutjnl-2021-326562 – ident: 2022100307301820000_12.10.e067265.8 doi: 10.1093/ecco-jcc/jjac062 – ident: 2022100307301820000_12.10.e067265.42 doi: 10.1016/0895-4356(95)00048-8 – ident: 2022100307301820000_12.10.e067265.3 doi: 10.1038/nrgastro.2013.31 – ident: 2022100307301820000_12.10.e067265.2 doi: 10.1136/gutjnl-2019-318484 – ident: 2022100307301820000_12.10.e067265.29 doi: 10.1136/bmj.e7586 – ident: 2022100307301820000_12.10.e067265.32 doi: 10.1093/ecco-jcc/jjx156 – ident: 2022100307301820000_12.10.e067265.9 doi: 10.1093/ecco-jcc/jjw168 – ident: 2022100307301820000_12.10.e067265.41 doi: 10.1016/j.jclinepi.2004.06.017 – ident: 2022100307301820000_12.10.e067265.12 doi: 10.1053/j.gastro.2019.03.051 – ident: 2022100307301820000_12.10.e067265.23 doi: 10.1016/S0140-6736(15)00068-9 – volume: 11 start-page: 274 year: 2017 ident: 2022100307301820000_12.10.e067265.27 article-title: Prevalence of bowel damage assessed by cross-sectional imaging in early crohn's disease and its impact on disease outcome publication-title: J Crohns Colitis |
| SSID | ssj0000459552 |
| Score | 2.3258855 |
| Snippet | IntroductionCrohn’s disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to... Crohn's disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to suppress... Introduction Crohn’s disease (CD) is characterised by discontinuous, relapsing enteric inflammation. Instituting advanced therapies at an early stage to... |
| SourceID | doaj pubmedcentral proquest pubmed crossref bmj |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | e067265 |
| SubjectTerms | Adult Adult gastroenterology Colon Crohn Disease - drug therapy Crohn's disease Endoscopy Gastrointestinal imaging Health services Humans Inflammation Inflammatory bowel disease Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy Medical diagnosis Medical prognosis Multicenter Studies as Topic Patients Prospective Studies RADIOLOGY & IMAGING Radiology and Imaging Small intestine State Medicine Ultrasonic imaging |
| SummonAdditionalLinks | – databaseName: BMJ Open Access Journals (WRLC) dbid: 9YT link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3NbtQwELbaIlW9IP4JFGQkDhzWbWLHicMNVrsqSMsBbaVyihLbaYt2kypND9z6EFx4E56nT8KM4wQWoYrTSsk46-zMrL_xzHwm5LXQKlYQdLGswK2bLLRMiVgzDeZVplXKC9e3tviUHB3HH0_kyRbhQy9Muf6Kx0YdwGff0YAcTXV3GHHw70OLicNEHuDW9Da5g4eTYBlX9mU57qsARMmkO2iHh3HMAK1LTzYUiWR4PNgGxGD9w_bIrsAoIsRs6DYIbKxQjsj_X-jz7yLKP1al-T1y18NJ-q7X_32yZesHZHfhE-YPyc_FbPn5w5TN5m_pujitsWWRQoTdIM-GpUjI2XrSato19KLFkR01yLyLjerUJ3DoeU0BgK--wQVXm2cNnbbNWX1z_eNyELq5_o60Dw3YFgUsTAvqyhXd1O2E1k3NYGU0DZiWNROKuxQry4p2PYEvboaeT-oYbx-R4_lsOT1i_rAGVkqRdcxUgPXiElw8s4mKqsSqSqSp5lZWPJVRoUAitGUF_xEig6C8klqmlU54pqQOhXhMdmAe9imhRkihrUmNRCYaLlWhkrAwoix0bHkWB-QNqCn3znaZuzhGJLlXbo7KzXvlBoQPusy1Jz3HszdWtw-ajIMues6P28Xfo5GMokjY7S407Wnu_T8PbRgpFZfcVACoICaOjAKLA_ilAYRrE5D9wcR-vxhSDyWxAogXkFfjbVASJnWK2jZXKAPgI0EkHJAnvUWOMxnsOiDphq1uTHXzTn1-5jjGMykA6fJn__9TPyd7zquwuELsk52uvbIvALB15Uvnob8AvVo9DA priority: 102 providerName: BMJ Publishing Group Ltd – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NjtMwELZgkRAXxD9ZFmQkDhxqbWLHicMFQdVqQSoHtCv1FiW2sz9qk26aPXDbh-DCm_A8-yTMuE6WItSrY8uOZsb-xjP-hpB3QqtYgdPFsgKvbrLQMiVizTSoV5lWKS_cu7XZt-ToJP46l3N_4bb2aZX9nug2atNovCM_RBqWJFZw3H1cXTKsGoXRVV9C4y65h9RlmNKVztPhjgXgSiYl92RDkUgOy-UFVqUC3QAfDKOQ7lCB1q1jybH3_w9y_ps5-ddRNH1EHnoMST9thP6Y3LH1E3J_5qPkT8nv2eT4-5cxm0w_0GVxWuM7RQpudYPkGpYiC2frmapp19BViyM7apBuF1-nUx-1oec1BdS9-AENLiHPGjpum7P65vrXuu90c_0TuR4aUCgKAJgW1OUouqXbEa2bmsFxaBrQJ2tGFK8mFpYV7XIEEzf9Q0_qaG6fkZPp5Hh8xHyFBlZKkXXMVADw4hLsOrOJiqrEqkqkqeZWVjyVUaGgR2jLCjYGkYEnXkkt00onPFNSh0I8J3uwDvuSUCOk0NakRiL9DJeqUElYGFEWOrY8iwPyHsSUewtb5855EUnuJZqjRPONRAPCe1nm2jOdY8GNxe5Bo2HQakP0sbv7Z1SSoSuydLuGpj3NvdHnoQ0jpeKSmwpQFDjCkVFhxgFzaUDe2gTkoFex2x-7VfSAvB0-g5AwklPUtrnCPoA4EoS_AXmx0chhJQJdYpglIOmWrm4tdftLfX7miMUzKQDe8v3dy3pFHjjzwSwKcUD2uvbKvgZk1pVvnPn9AQaWO74 priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELZKkRAXxH9TCjISBw4byNpxYiMhBKtdFaTlgLpSb5FjO23RbtKmqURvfQguvAnP0ydhxussLCo9cbXHipOZ8XwT298Q8oIbmUpIumKl8deNSlwseWpiA-ZV5lXOtL-3Nv2c7c7ST_tif4P0VVHDBzy9MrXDelKzdv7q28n5O3D4t6Eiyety8RW7QOGQWOHWYiZukJsQmnL01GnA-35pToUSggX2oX-MhSgDrWtxytP5X4VB_z5K-UdsmtwldwKopO-XVnCPbLj6Prk1DdvmD8jP6Xjvy8dRPJ68oQt9UOPFRQp5doNsG44iLWcbqKtp19DjFkd21CL_Ll5Xp2Ebhx7VFGD4_Bwa_Ak9Z-mobQ7ry4sfp73Q5cV3JH9owMIoIGKqqT-06KfuBrRu6hjio23AwJwdUPxXMXexbhcDeHDT3_yknvf2IZlNxnuj3TiUbIhLwVUX2woQX1qCoyuXyWGVOVnxPDfMiYrlYqglSCSurGCl4ApS80oYkVcmY0oKk3D-iGzCPNwWoZYLbpzNrUA-GiakllmiLS-1SR1TaURegpqK3mIKn83wrAgaLVCjxVKjEWG9LgsTqM-xAsf8-kGD1aDjJfPH9eIf0EhWokjb7Rua9qAIq0CRuGQoZVoyWwGsgsx4aGWiGIAwA1Dc2Ijs9Cb2-8WQgChLJQC9iDxfdYOScGtH1645QxmAIBni4Yg8XlrkaiYcc2R4SkTyNVtdm-p6T3106JnGleCAd9n2_3i3J-S2dzI8fMF3yGbXnrmnAOi68pl30l-UD0yQ priority: 102 providerName: Scholars Portal |
| Title | METRIC-EF: magnetic resonance enterography to predict disabling disease in newly diagnosed Crohn’s disease—protocol for a multicentre, non-randomised, single-arm, prospective study |
| URI | https://bmjopen.bmj.com/content/12/10/e067265.full https://www.ncbi.nlm.nih.gov/pubmed/36192092 https://www.proquest.com/docview/2734648317 https://www.proquest.com/docview/2721260154 https://pubmed.ncbi.nlm.nih.gov/PMC9535152 https://doaj.org/article/0e01884b2df2444481d8092201c013cd |
| Volume | 12 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELagSIgL4p_QsjISBw4bNbHjxObWrnYpSKlQtUXLKUpspy3aTao0PfTWh-DCm_A8fRJmnOyyi1C5cHEkx1aczGfPN7H9mZC3XMtIQtDlqxx_3ajA-pJH2tcAryIpE5a7fWvpYXxwHH2aidnaUV-4JqyTB-4-3G5gg1DKqGCmBE8EwURoZKAY-C0N7EUbHH3B560FU24MjoQSgvUyQyGPd4vFNzyPClAB0RfOPzp3ArkbDsnp9v-NbP65ZnLNCU0ekYc9e6R7Xasfkzu2ekLup_38-FPyMx1Pjz6O_PHkPV3kJxXuUKQQUNcoq2Ep6m82vUY1bWt63mDNlhoU2sV96bSfr6FnFQW-Pb-CDLcUzxo6aurT6ub6x8Wy0M31d1R5qAFKFKgvzalbneiaboe0qisfHKGpAUnWDCn-lJhbP28WQ3hwvdziSZ3A7TNyPBlPRwd-fzaDXwiuWt-UQO2iAnq0srEMy9jKkieJZlaULBFhLqFEYIsShgSuIAYvhRZJqWOmpNAB58_JFrTDviTUcMG1NYkRKDzDhMxlHOSGF7mOLFORR96BmbK-b11kLmzhcdZbNEOLZp1FPcKWtsx0r3GOR23Mb680XFU67yQ-bi--jyBZFUV9bpcBqM161Gb_Qq1HdpYQ-_1iqDQURxIYnUferG6DkXAOJ69sfYllgGvESHw98qJD5KolHINheIpHkg2sbjR18051duokxZXgQGzZq__xbtvkgetkuMqC75Cttrm0r4G5tcWA3E1mCaTq63RA7u2N0vQLXPfHh5-PBq4DQ_phFkKaRvIXt-tJiQ |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dbtMwFLamTgJuEP9kG2AkkLhotNSOEwcJIVZatWyt0NRJuwuJ7WxDbVLSTmh3ewhueAmueZ49Cee4SUcR6t1uHVt2dD7b37GPv0PIK66kL8HpcqMEj24iz7iS-8pVAK80zEKW2Hdrg2HQO_I_HYvjDfKrfguDYZX1mmgXal0oPCPfRRmWwJew3b2ffnMxaxTertYpNBaw2DcX38Flm73rfwT7vmas2xm1e26VVcBNBY_mrs6AlPgpYDEygWxlgZEZD0PFjMhYKFqJhBqeSTMAM4_Ae8yEEmGmAhZJoTw8AIUlf9Pn4Mo0yOZeZ_j5cHmqAwQpEoJV8kYtHuymk6-YBwvQCF4f3nvabQxKVzZCmy_gfyT331jNvza_7j1yt2Kt9MMCZvfJhskfkFuD6l7-Ifk96IwO-223031LJ8lJji8jKTjyBcp5GIq6n2WljU3nBZ2W2HJONQr84nt4Wt0T0bOcAs8fX0CBDQE0mrbL4jS_uvw5qytdXf5AdYkCIEyBctOE2qhIO3TTpHmRu7AB6wIQbHST4mHI2LhJOWlCx0X9tJRaYd1H5OhGrPeYNGAc5imhmguujA61QMEbJmQiAy_RPE2Ub1jkO-QNmCmu5vQstu4SD-LKojFaNF5Y1CGstmWsKm11TPExXt-ouWw0XUiLrK--hyBZVkVdcFtQlCdxtczEnvFaUvop0xnwNnC9W1p6EQOWp4DrK-2QnRpi1z92PbUc8nL5GYyEd0dJbopzrAMcJ0DC7ZAnC0QuR8LRCYdeHBKuYHVlqKtf8rNTK2UeCQ6Emm2tH9YLcrs3GhzEB_3h_ja5Y6cSxnDwHdKYl-fmGfDCefq8moyUfLnp-f8HfMF4-Q |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dbtMwFLamIU3cIP7JGGAkkLho1MSOEwcJIeharYxOCG1S70JiO9tQm5S0E9rdHoIb3gTxOHsSznGSjiLUu90mtuLofMf-jn38HUJecCUDCUGXG6e4dRN7xpU8UK4CeGVRHrHU3lsbHYR7R8GHsRhvkN_tXRhMq2znRDtR61LhHnkXZVjCQMJy182btIhPu4O3s28uVpDCk9a2nEYNkX1z_h3Ct_mb4S7Y-iVjg_5hb89tKgy4meDxwtU5EJQgA1zGJpR-HhqZ8yhSzIicRcJPJbTwTJYDsHkMkWQulIhyFbJYCuXhZihM_zciLnz0sWgcLfd3gCrFQrBG6MjnYTebfsWKWIBLiP_wBNQuaPB0ZUm0lQP-R3f_zdr8axkc3Ca3Gv5K39WAu0M2THGXbI2aE_p75Neof_h52HP7g9d0mh4XeEeSQkhforCHoagAWjUq2XRR0lmFPRdUo9Qv3oynzYkRPS0oMP7JOTywyYBG015VnhSXFz_nbaPLix-oM1ECmCmQb5pSmx9ph246tCgLF5ZiXQKWje5Q3BaZGDetph34cNleMqVWYvc-OboW2z0gmzAO84hQzQVXRkdaoPQNEzKVoZdqnqUqMCwOHPIKzJQ03j1PbODEw6SxaIIWTWqLOoS1tkxUo7KOxT4m6zt1lp1mtcjI-ubvESTLpqgQbh-U1XHSTDiJZzxfyiBjOgcGB0G4r6UXM-B7Cli_0g7ZaSF29WNXTuaQ58vXYCQ8RUoLU55hG2A7IVJvhzysEbkcCcdwHL7ikGgFqytDXX1TnJ5YUfNYgBMJtr1-WM_IFnh98nF4sP-Y3LSehMkcfIdsLqoz8wQI4iJ7aj2Rki_X7fp_AJUme8k |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=METRIC-EF%3A+magnetic+resonance+enterography+to+predict+disabling+disease+in+newly+diagnosed+Crohn%E2%80%99s+disease%E2%80%94protocol+for+a+multicentre%2C+non-randomised%2C+single-arm%2C+prospective+study&rft.jtitle=BMJ+open&rft.au=Ailsa+L+Hart&rft.au=Gauraang+Bhatnagar&rft.au=Stuart+Bloom&rft.au=Steve+Halligan&rft.date=2022-10-03&rft.pub=BMJ+Publishing+Group&rft.eissn=2044-6055&rft.volume=12&rft.issue=10&rft_id=info:doi/10.1136%2Fbmjopen-2022-067265&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_0e01884b2df2444481d8092201c013cd |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2044-6055&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2044-6055&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2044-6055&client=summon |