Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

• Published in: Gut Vol. 66; no. 3; pp. 464 - 472
• Main Authors: Møller, Pål, Seppälä, Toni, Bernstein, Inge, Holinski-Feder, Elke, Sala, Paola, Evans, D Gareth, Lindblom, Annika, Macrae, Finlay, Blanco, Ignacio, Sijmons, Rolf, Jeffries, Jacqueline, Vasen, Hans, Burn, John, Nakken, Sigve, Hovig, Eivind, Rødland, Einar Andreas, Tharmaratnam, Kukatharmini, de Vos tot Nederveen Cappel, Wouter H, Hill, James, Wijnen, Juul, Green, Kate, Lalloo, Fiona, Sunde, Lone, Mints, Miriam, Bertario, Lucio, Pineda, Marta, Navarro, Matilde, Morak, Monika, Renkonen-Sinisalo, Laura, Frayling, Ian M, Plazzer, John-Paul, Pylvanainen, Kirsi, Sampson, Julian R, Capella, Gabriel, Mecklin, Jukka-Pekka, Möslein, Gabriela
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.03.2017; BMJ Publishing Group
• Series: Original article
• Subjects: Adolescent; Adult; Age Factors; Age groups; Aged; Aged, 80 and over; Child; Colon; Colonoscopy; Colorectal cancer; Colorectal Neoplasms, Hereditary Nonpolyposis - diagnostic imaging; Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics; Colorectal Neoplasms, Hereditary Nonpolyposis - mortality; Databases, Factual; DNA-Binding Proteins - genetics; Endometrial cancer; Endometrial Neoplasms - epidemiology; Endometrial Neoplasms - mortality; Female; Gene Expression; Genes; Genetic engineering; Gynecology; Heterozygote; Humans; Hysterectomy; Incidence; Male; Middle Aged; Mismatch Repair Endonuclease PMS2 - genetics; Mutation; MutL Protein Homolog 1 - genetics; MutS Homolog 2 Protein - genetics; Oophorectomy; Ovarian cancer; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - mortality; Patients; Population Surveillance; Prevention; Prospective Studies; Surveillance; Survival Rate; Tumors; Young Adult; CANCER SYNDROMES; COLONOSCOPY; COLORECTAL CANCER; CANCER PREVENTION; CANCER GENETICS

ObjectiveEstimates of cancer risk and the effects of surveillance in Lynch syndrome have been subject to bias, partly through reliance on retrospective studies. We sought to establish more robust estimates in patients undergoing prospective cancer surveillance.DesignWe undertook a multicentre study...