Vigabatrin and depression

Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying b...

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Bibliographic Details
Published inJournal of neurology, neurosurgery and psychiatry Vol. 56; no. 8; pp. 925 - 928
Main Authors Ring, H A, Crellin, R, Kirker, S, Reynolds, E H
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group Ltd 01.08.1993
BMJ
BMJ Publishing Group LTD
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Summary:Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying between 1.5 g and 4 g a day, often but not always when patients were experiencing a decrease in their seizure frequency. Most patients had a history of affective disturbance, sometimes in association with other GABAergic drugs. The observations support a possible role for GABAergic mechanisms in the biology of mood disorders.
Bibliography:PMID:8350115
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ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.56.8.925