Vigabatrin and depression
Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying b...
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Published in | Journal of neurology, neurosurgery and psychiatry Vol. 56; no. 8; pp. 925 - 928 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
London
BMJ Publishing Group Ltd
01.08.1993
BMJ BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | Ten patients who developed a major depressive episode in association with vigabatrin treatment for intractable epilepsy are reported. The depression usually occurred early in the course of treatment, but when delayed followed a recent increase in dose. Depressive symptoms occurred at doses varying between 1.5 g and 4 g a day, often but not always when patients were experiencing a decrease in their seizure frequency. Most patients had a history of affective disturbance, sometimes in association with other GABAergic drugs. The observations support a possible role for GABAergic mechanisms in the biology of mood disorders. |
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Bibliography: | PMID:8350115 href:jnnp-56-925.pdf local:jnnp;56/8/925 istex:15C7CE7B8FBF7086CC17CFC7EFF0131FCCC7A638 ark:/67375/NVC-LW2NZ4FM-X |
ISSN: | 0022-3050 1468-330X |
DOI: | 10.1136/jnnp.56.8.925 |