Brain natriuretic peptide is released from human astrocytoma cell line U373MG under hypoxia: a possible role in anti-apoptosis

• Published in: Journal of endocrinology Vol. 208; no. 1; pp. 51 - 57
• Main Authors: Katoh, Chisato, Osanai, Tomohiro, Tomita, Hirofumi, Okumura, Ken
• Format: Journal Article
• Language: English
• Published: Bristol BioScientifica 01.01.2011
• Subjects: Analysis of Variance; Apoptosis - physiology; Astrocytes - metabolism; Astrocytes - secretion; Biological and medical sciences; Blotting, Western; Cell Line, Tumor; Fundamental and applied biological sciences. Psychology; Humans; Hypoxia - genetics; Hypoxia - metabolism; Immunoenzyme Techniques; Medical sciences; Natriuretic Peptide, Brain - genetics; Natriuretic Peptide, Brain - metabolism; Natriuretic Peptide, Brain - secretion; Neurology; Phosphorylation; Regular papers; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured - metabolism; Tumor Cells, Cultured - secretion; Tumors of the nervous system. Phacomatoses; Vertebrates: endocrinology; Human; Brain natriuretic peptide; Nervous system diseases; Oxygen; Environmental factor; Cell line; Glioma; Cell death; Central nervous system disease; Tumor; Hypoxia; Astrocytoma; Apoptosis

We have recently shown that the plasma brain-type natriuretic peptide (BNP) level is elevated in acute ischemic stroke patients, but the origin and role of BNP remain unclear. We investigated whether human astrocytes secrete BNP under hypoxia, and if so, what signaling pathway is involved, and what...