Early neurological deterioration in acute ischaemic stroke: predictors, mechanisms and management

• Published in: Postgraduate medical journal Vol. 84; no. 994; pp. 412 - 417
• Main Authors: Thanvi, B, Treadwell, S, Robinson, T
• Format: Journal Article
• Language: English
• Published: London The Fellowship of Postgraduate Medicine 01.08.2008; BMJ; Oxford University Press
• Subjects: acute stroke; Biological and medical sciences; Blood pressure; Brain Edema - etiology; Brain Ischemia - diagnosis; Brain Ischemia - therapy; Cardiac arrhythmia; Collateral Circulation; Consciousness; Diabetes; Disease Progression; early neurologic deterioration; General aspects; Humans; Medical sciences; Mortality; Nervous System Diseases - etiology; Nervous System Diseases - therapy; neurologic; Neurology; Seizures - etiology; Stroke; Stroke - diagnosis; Stroke - therapy; Terminology as Topic; Vascular diseases and vascular malformations of the nervous system; Veins & arteries; Nervous system diseases; Acute; Prediction; Cardiovascular disease; Nervous system; Mechanism; Cerebral disorder; Vascular disease; Medicine; Clinical management; Central nervous system disease; Brain ischemia; Early; Predictive factor; Cerebrovascular disease

Early neurological deterioration (END) in acute ischaemic stroke is a common event. The underlying mechanisms are heterogeneous. The clinical predictors of END include severity of the initial stroke, large vessel occlusion, diabetes mellitus, hypotension, and atrial fibrillation. Serial observations...