B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis

• Published in: Annals of the rheumatic diseases Vol. 74; no. 1; pp. 294 - 302
• Main Authors: Rapetti, Laetitia, Chavele, Konstantia-Maria, Evans, Catherine M, Ehrenstein, Michael R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.01.2015
• Subjects: Apoptosis - physiology; Arthritis, Rheumatoid - immunology; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Case-Control Studies; Colleges & universities; fas Receptor - metabolism; Female; Flow Cytometry; Humans; Leukocytes, Mononuclear - immunology; Lymphocyte Activation - immunology; Lymphocyte receptors; Male; Rheumatoid arthritis; Rodents; T cell receptors; T-Lymphocytes, Regulatory - immunology; Autoimmunity; T Cells; B cells; Rheumatoid Arthritis

Objective To investigate whether regulatory T cells (Treg) can control B cell function in rheumatoid arthritis (RA) and if not to explore the basis for this defect. Methods Suppression of B cell responses by Treg was analysed in vitro by flow cytometry and ELISA using peripheral blood mononuclear ce...