Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial

• Published in: Gut Vol. 73; no. 2; pp. 298 - 310
• Main Authors: Medawar, Evelyn, Beyer, Frauke, Thieleking, Ronja, Haange, Sven-Bastiaan, Rolle-Kampczyk, Ulrike, Reinicke, Madlen, Chakaroun, Rima, von Bergen, Martin, Stumvoll, Michael, Villringer, Arno, Witte, A Veronica
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.02.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: ABC transporter; Animals; Blood levels; Body mass index; Body weight; BRAIN IMAGING; Brain research; BRAIN/GUT INTERACTION; Cross-Over Studies; Decision making; Diet; DIETARY FIBRE; Digestive system; Eating behavior; Fasting; Fatty acids; Fatty Acids, Volatile - metabolism; Feces - microbiology; Female; Food; Functional magnetic resonance imaging; Gastroenterologi och hepatologi; Gastroenterology and Hepatology; Gastrointestinal surgery; Gastrointestinal tract; Gut Microbiota; Humans; Hypotheses; Inflammation; Intestinal microflora; Inulin; Magnetic resonance imaging; Medical imaging; Microbiomes; Microbiota; Neuroimaging; OBESITY; Overweight; Pandemics; Placebos; Plants; Prebiotics; Questionnaires; Reinforcement; rRNA 16S; SHORT CHAIN FATTY ACIDS; Signal transduction; Ventral tegmentum; Weight control; Womens health; Young Adult; Young adults; Germany; DIETARY FIBRE; OBESITY; BRAIN/GUT INTERACTION; BRAIN IMAGING; SHORT CHAIN FATTY ACIDS

ObjectiveAnimal studies suggest that prebiotic, plant-derived nutrients could improve homoeostatic and hedonic brain functions through improvements in microbiome–gut–brain communication. However, little is known if these results are applicable to humans. Therefore, we tested the effects of high-dose...