Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expression

• Published in: Journal of endocrinology Vol. 191; no. 3; pp. 651 - 663
• Main Authors: Wilson, Andrea C, Salamat, M Shahriar, Haasl, Ryan J, Roche, Kelly M, Karande, Anjali, Meethal, Sivan Vadakkadath, Terasawa, Ei, Bowen, Richard L, Atwood, Craig S
• Format: Journal Article
• Language: English
• Published: Colchester BioScientifica 01.12.2006; Portland Press
• Subjects: Alzheimer Disease - metabolism; Animals; Animals, Newborn; Biological and medical sciences; Case-Control Studies; Cell Line, Tumor - chemistry; Cells, Cultured; Cerebral Cortex - metabolism; Fundamental and applied biological sciences. Psychology; Gonadotropin-Releasing Hormone - metabolism; Gonadotropin-Releasing Hormone - pharmacology; Hippocampus - metabolism; Hormones and neuropeptides. Regulation; Humans; Hypothalamus. Hypophysis. Epiphysis. Urophysis; Immunohistochemistry - methods; Luteinizing Hormone - analysis; Luteinizing Hormone - genetics; Luteinizing Hormone - metabolism; Neuroblastoma - chemistry; Neuroblastoma - secretion; Neurons - metabolism; Rats; Rats, Sprague-Dawley; Receptors, LHRH - analysis; Receptors, LHRH - genetics; Receptors, LHRH - metabolism; Regular papers; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; Vertebrates: endocrinology; Human; Rat; Rodentia; Central nervous system; Gonadotropin RH; Patient; Gonadotropin; Neuroblastoma; Gene expression; In vitro; Encephalon; Hypothalamic hormone; Vertebrata; Mammalia; Cell line; Adenohypophyseal hormone; Luteinizing hormone; Hormone releasing factor; Localization; Hippocampus; Biological receptor

Gonadotropin-releasing hormone receptor I (GnRHR I) has been localized to the limbic system of the rat brain, although the functional consequences of GnRH signaling through these receptors is unknown. In this paper, we characterize the expression of GnRHR I in the human hippocampus and cortex, and t...