Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach

• Published in: Gut Vol. 67; no. 9; pp. 1595 - 1605
• Main Authors: Choi, Eunyoung, Lantz, Tyler L, Vlacich, Gregory, Keeley, Theresa M, Samuelson, Linda C, Coffey, Robert J, Goldenring, James R, Powell, Anne E
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.09.2018
• Subjects: Animals; Atrophy; Biology; Biomarkers - metabolism; Cancer; Cell Lineage; Disease Models, Animal; Epidermal growth factor; Epithelial cells; Gastric glands; Gastric mucosa; Gastric Mucosa - drug effects; Gastric Mucosa - metabolism; Gastroenterology; Glands; Homeostasis; Intestine; Labeling; Ligands; Medical prognosis; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mice; Mice, Knockout; Mucous membrane; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Parietal cells; Predictive Value of Tests; Progenitor cells; Rodents; Sensitivity and Specificity; Skin; Small intestine; Stem cell transplantation; Stem cells; Stem Cells - metabolism; Stomach; Stomach Ulcer - chemically induced; Stomach Ulcer - genetics; Stomach Ulcer - metabolism; Wound Healing; Lrig1; parietal cell; SPEM; metaplasia; oxyntic atrophy; gastric stem/progenitor cell

ObjectiveLrig1 is a marker of proliferative and quiescent stem cells in the skin and intestine. We examined whether Lrig1-expressing cells are long-lived gastric progenitors in gastric glands in the mouse stomach. We also investigated how the Lrig1-expressing progenitor cells contribute to the regen...