Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality

• Published in: Thorax Vol. 69; no. 8; pp. 718 - 723
• Main Authors: Williams, Michelle C, Murchison, John T, Edwards, Lisa D, Agustí, Alvar, Bakke, Per, Calverley, Peter M A, Celli, Bartolome, Coxson, Harvey O, Crim, Courtney, Lomas, David A, Miller, Bruce E, Rennard, Steve, Silverman, Edwin K, Tal-Singer, Ruth, Vestbo, Jørgen, Wouters, Emiel, Yates, Julie C, van Beek, Edwin J R, Newby, David E, MacNee, William
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.08.2014
• Subjects: Adult; Aged; Asymptomatic; Biomarkers - blood; Calcification; Calcinosis - complications; Calcinosis - diagnostic imaging; Calcinosis - mortality; Calcinosis - physiopathology; Cardiovascular disease; Chronic obstructive pulmonary disease; Coronary Artery Disease - complications; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - mortality; Coronary Artery Disease - physiopathology; Coronary vessels; Dyspnea - physiopathology; Female; Humans; Longitudinal Studies; Lung diseases; Male; Middle Aged; Mortality; Phenotype; Physical Endurance; Predictive Value of Tests; Pulmonary Disease, Chronic Obstructive - complications; Pulmonary Disease, Chronic Obstructive - diagnostic imaging; Pulmonary Disease, Chronic Obstructive - mortality; Pulmonary Disease, Chronic Obstructive - physiopathology; Respiratory Function Tests; Risk Factors; Severity of Illness Index; Spirometry; Tomography, X-Ray Computed; COPD ÀÜ Mechanisms; Imaging/CT MRI etc; Emphysema

Background Coronary artery calcification is pathognomonic of coronary artery disease (CAD). Whether CAD in patients with COPD is linked to lung function, functional capacity and/or clinically relevant outcomes is unknown. The objective was to assess the association between CAD and disease severity,...