Association between polymorphisms in phospholipase A2 genes and the plasma triglyceride response to an n-3 PUFA supplementation: a clinical trial

• Published in: Lipids in health and disease Vol. 14; no. 1; p. 12
• Main Authors: Tremblay, Bénédicte L, Cormier, Hubert, Rudkowska, Iwona, Lemieux, Simone, Couture, Patrick, Vohl, Marie-Claude
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.02.2015; BioMed Central
• Subjects: 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics; Adult; Dietary Supplements; Fatty Acids, Omega-3 - therapeutic use; Female; Genetic Association Studies; Group II Phospholipases A2 - genetics; Group VI Phospholipases A2 - genetics; Humans; Male; Phospholipases A2 - genetics; Polymorphism, Single Nucleotide - genetics; Triglycerides - blood

Fish oil-derived long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), reduce plasma triglyceride (TG) levels. Genetic factors such as single-nucleotide polymorphisms (SNPs) found in genes involved in metabolic pathways of...