PKCα expression is a marker for breast cancer aggressiveness
Abstract Background Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes. Results In two cohorts of primary breast cancers, PKCα levels correlated to estro...
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| Published in | Molecular cancer Vol. 9; no. 1; p. 76 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
BioMed Central Ltd
14.04.2010
BioMed Central BMC |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Abstract
Background
Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes.
Results
In two cohorts of primary breast cancers, PKCα levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKCδ and PKCε did not correlate to clinicopathological parameters. Patients with PKCα-positive tumors showed poorer survival than patients with PKCα-negative tumors independently of other factors. Cell line studies demonstrated that PKCα levels are high in MDA-MB-231 and absent in T47D cells which proliferated slower than other cell lines. Furthermore, PKCα silencing reduced proliferation of MDA-MB-231 cells. PKCα inhibition or downregulation also reduced cell migration
in vitro
.
Conclusions
PKCα is a marker for poor prognosis of breast cancer and correlates to and is important for cell functions associated with breast cancer progression. |
|---|---|
| AbstractList | Abstract
Background
Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes.
Results
In two cohorts of primary breast cancers, PKCα levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKCδ and PKCε did not correlate to clinicopathological parameters. Patients with PKCα-positive tumors showed poorer survival than patients with PKCα-negative tumors independently of other factors. Cell line studies demonstrated that PKCα levels are high in MDA-MB-231 and absent in T47D cells which proliferated slower than other cell lines. Furthermore, PKCα silencing reduced proliferation of MDA-MB-231 cells. PKCα inhibition or downregulation also reduced cell migration
in vitro
.
Conclusions
PKCα is a marker for poor prognosis of breast cancer and correlates to and is important for cell functions associated with breast cancer progression. Background: Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes. Results: In two cohorts of primary breast cancers, PKC alpha levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKC delta and PKC epsilon did not correlate to clinicopathological parameters. Patients with PKC alpha-positive tumors showed poorer survival than patients with PKC alpha-negative tumors independently of other factors. Cell line studies demonstrated that PKC alpha levels are high in MDA-MB-231 and absent in T47D cells which proliferated slower than other cell lines. Furthermore, PKC alpha silencing reduced proliferation of MDA-MB-231 cells. PKC alpha inhibition or downregulation also reduced cell migration in vitro. Conclusions: PKC alpha is a marker for poor prognosis of breast cancer and correlates to and is important for cell functions associated with breast cancer progression. BACKGROUND: Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes. RESULTS: In two cohorts of primary breast cancers, PKCα levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKCδ and PKCε did not correlate to clinicopathological parameters. Patients with PKCα-positive tumors showed poorer survival than patients with PKCα-negative tumors independently of other factors. Cell line studies demonstrated that PKCα levels are high in MDA-MB-231 and absent in T47D cells which proliferated slower than other cell lines. Furthermore, PKCα silencing reduced proliferation of MDA-MB-231 cells. PKCα inhibition or downregulation also reduced cell migration in vitro. CONCLUSIONS: PKCα is a marker for poor prognosis of breast cancer and correlates to and is important for cell functions associated with breast cancer progression. Abstract Background Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes. Results In two cohorts of primary breast cancers, PKCα levels correlated to estrogen and progesterone receptor negativity, tumor grade, and proliferative activity, whereas PKCδ and PKCε did not correlate to clinicopathological parameters. Patients with PKCα-positive tumors showed poorer survival than patients with PKCα-negative tumors independently of other factors. Cell line studies demonstrated that PKCα levels are high in MDA-MB-231 and absent in T47D cells which proliferated slower than other cell lines. Furthermore, PKCα silencing reduced proliferation of MDA-MB-231 cells. PKCα inhibition or downregulation also reduced cell migration in vitro. Conclusions PKCα is a marker for poor prognosis of breast cancer and correlates to and is important for cell functions associated with breast cancer progression. |
| ArticleNumber | 76 |
| Author | Zahirovic, Iris Omanovic Larsson, Christer Cornmark, Louise Lønne, Gry Kalstad Jirström, Karin Landberg, Göran |
| AuthorAffiliation | 1 Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, SE- 205 02 Malmö, Sweden |
| AuthorAffiliation_xml | – name: 1 Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, SE- 205 02 Malmö, Sweden |
| Author_xml | – sequence: 1 givenname: Gry Kalstad surname: Lønne fullname: Lønne, Gry Kalstad – sequence: 2 givenname: Louise surname: Cornmark fullname: Cornmark, Louise – sequence: 3 givenname: Iris Omanovic surname: Zahirovic fullname: Zahirovic, Iris Omanovic – sequence: 4 givenname: Göran surname: Landberg fullname: Landberg, Göran – sequence: 5 givenname: Karin surname: Jirström fullname: Jirström, Karin – sequence: 6 givenname: Christer surname: Larsson fullname: Larsson, Christer |
| BackLink | https://lup.lub.lu.se/record/1631795$$DView record from Swedish Publication Index |
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Background
Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms... BACKGROUND: Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be... Background: Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be... Abstract Background Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms... |
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| SubjectTerms | Cancer and Oncology Cancer och onkologi Clinical Medicine Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap |
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| Title | PKCα expression is a marker for breast cancer aggressiveness |
| URI | http://dx.doi.org/10.1186/1476-4598-9-76 https://pubmed.ncbi.nlm.nih.gov/PMC2873434 https://lup.lub.lu.se/record/1631795 https://doaj.org/article/5f7ca4a4508f410182500744417a9e5c |
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