B7 score and T cell infiltration stratify immune status in prostate cancer

• Published in: Journal for immunotherapy of cancer Vol. 9; no. 8; p. e002455
• Main Authors: Zhou, Qianghua, Li, Kaiwen, Lai, Yiming, Yao, Kai, Wang, Qiong, Zhan, Xiangyu, Peng, Shirong, Cai, Wenli, Yao, Wei, Zang, Xingxing, Xu, Kewei, Huang, Jian, Huang, Hai
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.08.2021; BMJ Publishing Group
• Series: Original research
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - metabolism; Cancer; Cancer therapies; Humans; Immune checkpoint inhibitors; Immunotherapy; Immunotherapy Biomarkers; Kidney cancer; Ligands; Lung cancer; Lymphocytes, Tumor-Infiltrating - immunology; Male; Medical prognosis; Middle Aged; Prostate cancer; Prostatic Neoplasms - immunology; Retrospective Studies; Tumor Microenvironment; Tumors; United States > US; tumor microenvironment; tumor biomarkers; costimulatory and inhibitory T-cell receptors; prostatic neoplasms

BackgroundAlthough immune checkpoint inhibitors (ICIs), especially programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) axis blockers, exhibit prominent antitumor effects against numerous malignancies, their benefit for patients with prostate cancer (PCa) has been somewhat margin...