Baseline prevalence and longitudinal evolution of non-motor symptoms in early Parkinson’s disease: the PPMI cohort

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 89; no. 1; pp. 78 - 88
• Main Authors: Simuni, Tanya, Caspell-Garcia, Chelsea, Coffey, Christopher S, Weintraub, Daniel, Mollenhauer, Brit, Lasch, Shirley, Tanner, Caroline M, Jennings, Danna, Kieburtz, Karl, Chahine, Lana M, Marek, Kenneth
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.01.2018; BMJ Publishing Group
• Series: Research paper
• Subjects: Age Factors; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - genetics; Biomarkers - cerebrospinal fluid; Disease Progression; Early Diagnosis; Female; Humans; Longitudinal Studies; Male; Middle Aged; Movement Disorders; Parkinson Disease - cerebrospinal fluid; Parkinson Disease - diagnosis; Parkinson's disease; Prevalence; Prospective Studies; Severity of Illness Index; Sex Factors; non-motor symptoms; parkinson’s disease; biomarkers

ObjectiveTo examine the baseline prevalence and longitudinal evolution in non-motor symptoms (NMS) in a prospective cohort of, at baseline, patients with de novo Parkinson’s disease (PD) compared with healthy controls (HC).MethodsParkinson’s Progression Markers Initiative (PPMI) is a longitudinal, o...