Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis

• Published in: Journal for immunotherapy of cancer Vol. 9; no. 8; p. e003031
• Main Authors: Zhou, Yu-Fu, Song, Shu-Shu, Tian, Meng-Xin, Tang, Zheng, Wang, Han, Fang, Yuan, Qu, Wei-Feng, Jiang, Xi-Fei, Tao, Chen-Yang, Huang, Run, Zhou, Pei-Yun, Zhu, Shi-Guo, Zhou, Jian, Fan, Jia, Liu, Wei-Ren, Shi, Ying-Hong
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.08.2021; BMJ Publishing Group
• Series: Original research
• Subjects: Animals; Apoptosis; Apoptosis - physiology; Basic Tumor Immunology; Cancer; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cystathionine beta-Synthase - biosynthesis; Cystathionine beta-Synthase - immunology; Cystathionine beta-Synthase - metabolism; Cytokines; Enzymes; Homeodomain Proteins - immunology; Homeodomain Proteins - metabolism; Humans; Hydrogen Sulfide - immunology; Hydrogen Sulfide - metabolism; Immunotherapy; Interleukin-6 - immunology; Interleukin-6 - metabolism; Liver cancer; Liver Neoplasms - immunology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Lymphocytes; Medical prognosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Proteins; Signal Transduction; Software; STAT3 Transcription Factor - immunology; STAT3 Transcription Factor - metabolism; Statistical analysis; Survival analysis; T-Lymphocytes, Regulatory - immunology; Tumor Escape; Tumor Microenvironment; Tumorigenesis; liver neoplasms; immune evation; lymphocytes; tumor microenvironment; tumor escape; tumor-infiltrating

BackgroundHepatocellular carcinoma (HCC) is characterized by inflammation and immunopathogenesis. Accumulating evidence has shown that the cystathionine β-synthase/hydrogen sulfide (CBS/H2S) axis is involved in the regulation of inflammation. However, roles of CBS in HCC development and immune evasi...