Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis - Zhou, Yu-Fu; Song, Shu-Shu; Tian, Meng-Xin; Tang, Zheng; Wang, Han; Fang, Yuan; Qu, Wei-Feng; Jiang, Xi-Fei; Tao, Chen-Yang; Huang, Run; Zhou, Pei-Yun; Zhu, Shi-Guo; et al. (Journal for immunotherapy of cancer, 2021)
Keywords: Animals; Apoptosis; Apoptosis - physiology; Basic Tumor Immunology; Cancer; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cystathionine beta-Synthase - biosynthesis; Cystathionine beta-Synthase - immunology; Cystathionine beta-Synthase - metabolism; Cytokines; Enzymes; Homeodomain Proteins - immunology; Homeodomain Proteins - metabolism; Humans; Hydrogen Sulfide - immunology; Hydrogen Sulfide - metabolism; Immunotherapy; Interleukin-6 - immunology; Interleukin-6 - metabolism; Liver cancer; Liver Neoplasms - immunology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Lymphocytes; Medical prognosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Proteins; Signal Transduction; Software; STAT3 Transcription Factor - immunology; STAT3 Transcription Factor - metabolism; Statistical analysis; Survival analysis; T-Lymphocytes, Regulatory - immunology; Tumor Escape; Tumor Microenvironment; Tumorigenesis; liver neoplasms; immune evation; lymphocytes; tumor microenvironment; tumor escape; tumor-infiltrating