Challenges and next steps in the advancement of immunotherapy: summary of the 2018 and 2020 National Cancer Institute workshops on cell-based immunotherapy for solid tumors

• Published in: Journal for immunotherapy of cancer Vol. 9; no. 7; p. e003048
• Main Authors: Fogli, Laura K, Aurigemma, Rosemarie, Sommers, Connie L, Singh, Anju, Bourcier, Kasia, Ernstoff, Marc S
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.07.2021; BMJ Publishing Group
• Subjects: Antigens; Cancer; Cancer therapies; Cell culture; Cell- and Tissue-Based Therapy - methods; Education - standards; Genetic engineering; Good Manufacturing Practice; History, 21st Century; Humans; Immune Cell Therapies and Immune Cell Engineering; Immunotherapy; Immunotherapy - methods; Lymphocytes; Manufacturing; Medical research; Metabolism; National Cancer Institute (U.S.); Neoplasms - drug therapy; Patients; R&D; Research & development; Tumors; United States; Workshops; United States; T-lymphocytes; chimeric antigen; adoptive; lymphocytes; receptors; cell therapy; immunotherapy; tumor-infiltrating

Cell-based immunotherapies have had remarkable success in the clinic, specifically in the treatment of hematologic malignancies. However, these strategies have had limited efficacy in patients with solid tumors. To better understand the challenges involved, the National Cancer Institute (NCI) conven...