Neoadjuvant chemoradiation alters biomarkers of anticancer immunotherapy responses in locally advanced rectal cancer

• Published in: Journal for immunotherapy of cancer Vol. 9; no. 3; p. e001610
• Main Authors: Seo, Incheol, Lee, Hye Won, Byun, Sang Jun, Park, Jee Young, Min, Hyeonji, Lee, Sung Hwan, Lee, Ju-Seog, Kim, Shin, Bae, Sung Uk
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.03.2021; BMJ Publishing Group
• Series: Original research
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - immunology; Adenocarcinoma - pathology; Adenocarcinoma - therapy; Bioinformatics; Biomarkers; Biomarkers, Tumor - genetics; Biopsy; Cancer; Cancer therapies; Chemoradiotherapy, Adjuvant; Colorectal cancer; Databases, Genetic; Encyclopedias; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genomes; HCT116 Cells; Humans; Immunotherapy; Immunotherapy Biomarkers; Neoadjuvant Therapy; Principal components analysis; Quality control; Radiation therapy; Rectal Neoplasms - genetics; Rectal Neoplasms - immunology; Rectal Neoplasms - pathology; Rectal Neoplasms - therapy; RNA-Seq; Time Factors; Transcriptome; Treatment Outcome; Tumor Microenvironment - immunology; United States > US; Maryland; California; radiotherapy; immunomodulation; radioimmunotherapy; genome instability; gene expression profiling

BackgroundNeoadjuvant chemoradiation therapy (CRT) is a widely used preoperative treatment strategy for locally advanced rectal cancer (LARC). However, a few studies have evaluated the molecular changes caused by neoadjuvant CRT in these cancer tissues. Here, we aimed to investigate changes in immun...