Determining minimal important change for the thyroid-related quality of life questionnaire ThyPRO
Objective ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO. Methods A total of 435 patients treated for be...
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Published in | Endocrine Connections Vol. 10; no. 3; pp. 316 - 324 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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01.03.2021
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Abstract | Objective ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO. Methods A total of 435 patients treated for benign thyroid diseases completed ThyPRO at baseline and 6 weeks following treatment initiation. At 6 weeks follow-up, patients also completed Global Rating of Change items. For each 0–100 scale, two MIC values were identified: An MIC for groups, using the receiver operating characteristic (ROC) curve method and an MIC for individual patients, using the Reliable Change Index. Results ROC analyses provided group-MIC estimates of 6.3–14.3 (score range 0–100). Evaluation of area under the curve (AUC) supported the robustness for 9 of 14 scales (AUC > 0.7). Reliable Change Index estimates of individual-MIC were 8.0–21.1. For all scales but two, the individual-MIC values were larger than the group-MIC values. Conclusions Interpretability of ThyPRO was improved by the establishment of MIC values, which was 6.3–14.3 for groups and 8.0–21.1 for individuals. Thus, estimates of which changes are clinically relevant, are now available for future studies. We recommend using MIC values found by ROC analyses to evaluate changes in groups of patients, whereas MIC values identified by a dual criterion, including the reliability of changes, should be used for individual patients, for example, to identify individual responders in clinical studies or practice. |
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AbstractList | ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO.
A total of 435 patients treated for benign thyroid diseases completed ThyPRO at baseline and 6 weeks following treatment initiation. At 6 weeks follow-up, patients also completed Global Rating of Change items. For each 0-100 scale, two MIC values were identified: An MIC for groups, using the receiver operating characteristic (ROC) curve method and an MIC for individual patients, using the Reliable Change Index.
ROC analyses provided group-MIC estimates of 6.3-14.3 (score range 0-100). Evaluation of area under the curve (AUC) supported the robustness for 9 of 14 scales (AUC > 0.7). Reliable Change Index estimates of individual-MIC were 8.0-21.1. For all scales but two, the individual-MIC values were larger than the group-MIC values.
Interpretability of ThyPRO was improved by the establishment of MIC values, which was 6.3-14.3 for groups and 8.0-21.1 for individuals. Thus, estimates of which changes are clinically relevant, are now available for future studies. We recommend using MIC values found by ROC analyses to evaluate changes in groups of patients, whereas MIC values identified by a dual criterion, including the reliability of changes, should be used for individual patients, for example, to identify individual responders in clinical studies or practice. Objective ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO. Methods A total of 435 patients treated for benign thyroid diseases completed ThyPRO at baseline and 6 weeks following treatment initiation. At 6 weeks follow-up, patients also completed Global Rating of Change items. For each 0–100 scale, two MIC values were identified: An MIC for groups, using the receiver operating characteristic (ROC) curve method and an MIC for individual patients, using the Reliable Change Index. Results ROC analyses provided group-MIC estimates of 6.3–14.3 (score range 0–100). Evaluation of area under the curve (AUC) supported the robustness for 9 of 14 scales (AUC > 0.7). Reliable Change Index estimates of individual-MIC were 8.0–21.1. For all scales but two, the individual-MIC values were larger than the group-MIC values. Conclusions Interpretability of ThyPRO was improved by the establishment of MIC values, which was 6.3–14.3 for groups and 8.0–21.1 for individuals. Thus, estimates of which changes are clinically relevant, are now available for future studies. We recommend using MIC values found by ROC analyses to evaluate changes in groups of patients, whereas MIC values identified by a dual criterion, including the reliability of changes, should be used for individual patients, for example, to identify individual responders in clinical studies or practice. Objective: ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO. Methods: A total of 435 patients treated for benign thyroid diseases completed ThyPRO at baseline and 6 weeks following treatment initiation. At 6 weeks follow-up, patients also completed Global Rating of Change items. For each 0–100 scale, two MIC values were identified: An MIC for groups, using the receiver operating char acteristic (ROC) curve method and an MIC for individual patients, using the Reliable Change Index. Results: ROC analyses provided group-MIC estimates of 6.3–14.3 (score range 0–100). Evaluation of area under the curve (AUC) supported the robustness for 9 of 14 scales (AUC > 0.7). Reliable Change Index estimates of individual-MIC were 8.0–21.1. For all scales but two, the individual-MIC values were larger than the group-MIC values. Conclusions: Interpretability of ThyPRO was improved by the establishment of MIC values, which was 6.3–14.3 for groups and 8.0–21.1 for individuals. Thus, estimates of which changes are clinically relevant, are now available for future studies. We recommend using MIC values found by ROC analyses to evaluate changes in groups of patients, whereas MIC values identified by a dual criterion, including the reliability of changes, should be used for individual patients, for example, to identify individual responders in clinical studies or practice. OBJECTIVEThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO. METHODSA total of 435 patients treated for benign thyroid diseases completed ThyPRO at baseline and 6 weeks following treatment initiation. At 6 weeks follow-up, patients also completed Global Rating of Change items. For each 0-100 scale, two MIC values were identified: An MIC for groups, using the receiver operating characteristic (ROC) curve method and an MIC for individual patients, using the Reliable Change Index. RESULTSROC analyses provided group-MIC estimates of 6.3-14.3 (score range 0-100). Evaluation of area under the curve (AUC) supported the robustness for 9 of 14 scales (AUC > 0.7). Reliable Change Index estimates of individual-MIC were 8.0-21.1. For all scales but two, the individual-MIC values were larger than the group-MIC values. CONCLUSIONSInterpretability of ThyPRO was improved by the establishment of MIC values, which was 6.3-14.3 for groups and 8.0-21.1 for individuals. Thus, estimates of which changes are clinically relevant, are now available for future studies. We recommend using MIC values found by ROC analyses to evaluate changes in groups of patients, whereas MIC values identified by a dual criterion, including the reliability of changes, should be used for individual patients, for example, to identify individual responders in clinical studies or practice. Objective ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose of this study was to determine values for minimal important change (MIC) for ThyPRO. Methods A total of 435 patients treated for benign thyroid diseases completed ThyPRO at baseline and 6 weeks following treatment initiation. At 6 weeks follow-up, patients also completed Global Rating of Change items. For each 0–100 scale, two MIC values were identified: An MIC for groups, using the receiver operating characteristic (ROC) curve method and an MIC for individual patients, using the Reliable Change Index. Results ROC analyses provided group-MIC estimates of 6.3–14.3 (score range 0–100). Evaluation of area under the curve (AUC) supported the robustness for 9 of 14 scales (AUC > 0.7). Reliable Change Index estimates of individual-MIC were 8.0–21.1. For all scales but two, the individual-MIC values were larger than the group-MIC values. Conclusions Interpretability of ThyPRO was improved by the establishment of MIC values, which was 6.3–14.3 for groups and 8.0–21.1 for individuals. Thus, estimates of which changes are clinically relevant, are now available for future studies. We recommend using MIC values found by ROC analyses to evaluate changes in groups of patients, whereas MIC values identified by a dual criterion, including the reliability of changes, should be used for individual patients, for example, to identify individual responders in clinical studies or practice. |
Author | Nordqvist, Selma Flora Cramon, Per Karkov Bjorner, Jakob Bue Groenvold, Mogens Boesen, Victor Brun Feldt-Rasmussen, Ulla Hegedüs, Laszlo Watt, Torquil Rasmussen, Åse Krogh Bonnema, Steen Joop |
AuthorAffiliation | Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark Department of Palliative Medicine, Bispebjerg Hospital, Copenhagen, Denmark Department of Internal Medicine, Herlev Gentofte Hospital, Copenhagen, Denmark Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark Department of Public Health, University of Copenhagen, Copenhagen, Denmark National Research Centre for the Working Environment, Copenhagen, Denmark QualityMetric Incorporated, LLC, Johnston, Rhode Island, USA |
AuthorAffiliation_xml | – name: Department of Internal Medicine, Herlev Gentofte Hospital, Copenhagen, Denmark – name: Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark – name: Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark – name: Department of Palliative Medicine, Bispebjerg Hospital, Copenhagen, Denmark – name: National Research Centre for the Working Environment, Copenhagen, Denmark – name: Department of Public Health, University of Copenhagen, Copenhagen, Denmark – name: QualityMetric Incorporated, LLC, Johnston, Rhode Island, USA – name: Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark – name: Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark |
Author_xml | – sequence: 1 givenname: Selma Flora surname: Nordqvist fullname: Nordqvist, Selma Flora organization: Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark – sequence: 2 givenname: Victor Brun surname: Boesen fullname: Boesen, Victor Brun organization: Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark – sequence: 3 givenname: Åse Krogh surname: Rasmussen fullname: Rasmussen, Åse Krogh organization: Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark – sequence: 4 givenname: Ulla surname: Feldt-Rasmussen fullname: Feldt-Rasmussen, Ulla organization: Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark – sequence: 5 givenname: Laszlo surname: Hegedüs fullname: Hegedüs, Laszlo organization: Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark – sequence: 6 givenname: Steen Joop surname: Bonnema fullname: Bonnema, Steen Joop organization: Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark – sequence: 7 givenname: Per Karkov surname: Cramon fullname: Cramon, Per Karkov organization: Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark – sequence: 8 givenname: Torquil surname: Watt fullname: Watt, Torquil email: Torquil.Watt@regionh.dk organization: Department of Internal Medicine, Herlev Gentofte Hospital, Copenhagen, Denmark – sequence: 9 givenname: Mogens surname: Groenvold fullname: Groenvold, Mogens organization: Department of Palliative Medicine, Bispebjerg Hospital, Copenhagen, Denmark – sequence: 10 givenname: Jakob Bue surname: Bjorner fullname: Bjorner, Jakob Bue organization: QualityMetric Incorporated, LLC, Johnston, Rhode Island, USA |
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Snippet | Objective ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained.... ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The purpose... Objective ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained.... OBJECTIVEThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained. The... Objective: ThyPRO is the standard thyroid patient-reported outcome (PRO). The change in scores that patients perceive as important remains to be ascertained.... |
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SubjectTerms | interpretability minimal important change patient-reported outcomes thypro thyroid-related quality of life |
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Title | Determining minimal important change for the thyroid-related quality of life questionnaire ThyPRO |
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