Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer

• Published in: Current neurovascular research Vol. 14; no. 3; p. 299
• Main Author: Maiese, Kenneth
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2017
• Subjects: Animals; Autophagy - genetics; Circadian Rhythm - physiology; Humans; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - physiopathology; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - physiopathology; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Parkinson's disease; nicotinamide; apoptosis; wingless; diabetes mellitus; mTOR Complex 2 (mTORC2); AMP activated protein kinase (AMPK); hamartin (tuberous sclerosis 1)/tuberin (tuberous sclerosis 2) (TSC1/TSC2); β-catenin; mTOR Complex 1 (mTORC1); aging-related disorders; sirtuin; nerve growth factor; RORE; circadian rhythm; Aging; Wnt; programmed cell death; Alzheimer's disease; space travel; cardiovascular disease; shift work; stem cells; autophagy; mechanistic target of rapamycin (mTOR); angiogenesis; nicotinamide adenine dinucleotide (NAD+); period (PER); Cryptochrome; Huntington's disease; REV-ERBα; clock genes; RORα; metabolism; silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1); suprachiasmatic nucleus; BMAL1; CLOCK; oxidative stress

The mammalian circadian clock and its associated clock genes are increasingly been recognized as critical components for a number of physiological and disease processes that extend beyond hormone release, thermal regulation, and sleep-wake cycles. New evidence suggests that clinical behavior disrupt...