Drug-membrane interactions: significance for medicinal chemistry

• Published in: Current medicinal chemistry Vol. 17; no. 17; p. 1795
• Main Authors: Lúcio, M, Lima, J L F C, Reis, S
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.06.2010
• Subjects: Cell Membrane - drug effects; Cell Membrane - metabolism; Drug Delivery Systems - methods; Humans; Lipid Bilayers - metabolism; Membrane Lipids - metabolism; Micelles; Pharmaceutical Preparations - metabolism; Pharmacology - methods

Generally drugs can act on the level of different biological membranes as well as inside the cells that are limited by membranes. Even in the latter situation, drugs must still interact with the membrane in order to cross it and reach their targets. For this reason, the efficiency of drugs to intera...