Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques

• Published in: Current HIV research Vol. 9; no. 5; p. 276
• Main Authors: Durudas, Andre, Chen, Hui-Ling, Gasper, Melanie A, Sundaravaradan, Vasudha, Milush, Jeffrey M, Silvestri, Guido, Johnson, Welkin, Giavedoni, Luis D, Sodora, Donald L
• Format: Journal Article
• Language: English
• Published: Netherlands 01.07.2011
• Subjects: Administration, Oral; Animals; Antigens, CD - analysis; Blood Cells - immunology; Cytokines - blood; Disease Models, Animal; DNA, Complementary - blood; Genotype; Immunity, Innate; Leukocytes, Mononuclear - metabolism; Leukocytes, Mononuclear - virology; Lymph Nodes - immunology; Macaca mulatta; Real-Time Polymerase Chain Reaction; RNA, Messenger - metabolism; RNA, Viral - blood; Simian Acquired Immunodeficiency Syndrome - immunology; Simian Acquired Immunodeficiency Syndrome - virology; Simian Immunodeficiency Virus - genetics; Simian Immunodeficiency Virus - immunology; T-Lymphocytes - immunology; Up-Regulation; Viral Load

Mucosal transmission of HIV predominately occurs during sexual intercourse or breast-feeding and generally results in a successful infection from just one or few founder virions. Here we assessed the impact of viral inoculum size on both viral and immune events within two groups of Rhesus macaques t...