Childhood onset arthritis is associated with an increased risk of fracture: a population based study using the General Practice Research Database

• Published in: Annals of the rheumatic diseases Vol. 65; no. 8; pp. 1074 - 1079
• Main Authors: Burnham, J M, Shults, J, Weinstein, R, Lewis, J D, Leonard, M B
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and European League Against Rheumatism 01.08.2006; Elsevier Limited; BMJ Group
• Subjects: Adolescent; Age; Age of Onset; Arm Bones - injuries; Arthritis; Arthritis, Juvenile - complications; Child; Child development; children; Chronic illnesses; Codes; confidence interval; Databases, Factual; Disease control; disease modifying antirheumatic drugs; DMARDs; dual x ray absorptiometry; DXA; Epidemiologic Methods; Epidemiology; Extended Report; Family Practice; Female; fracture; Fractures; Fractures, Bone - etiology; General Practice Research Database; GPRD; Humans; Hypotheses; Immunotherapy; incidence rate ratio; IRR; JIA; juvenile idiopathic arthritis; Leg Bones - injuries; Male; Medical imaging; Middle Aged; non-steroidal anti-inflammatory drugs; NSAIDs; Osteoporosis; Oxford Medical Information Systems; OXMIS; peripheral quantitative computed tomography; Population; pQCT; Primary care; rheumatoid arthritis; Studies; United Kingdom; up to standard; UTS

Background: Childhood onset arthritis is associated with low bone mass and strength. Objective: To determine whether childhood onset arthritis is associated with greater fracture risk. Methods: In a retrospective cohort study all subjects with onset of arthritis between 1 and 19 years of age in the...