Peripheral T cell lymphoma, not otherwise specified: the stuff of genes, dreams and therapies

• Published in: Journal of clinical pathology Vol. 61; no. 11; pp. 1160 - 1167
• Main Authors: Agostinelli, C, Piccaluga, P P, Went, P, Rossi, M, Gazzola, A, Righi, S, Sista, T, Campidelli, C, Zinzani, P L, Falini, B, Pileri, S A
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.11.2008; BMJ; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Biological and medical sciences; Biomarkers, Tumor - metabolism; Cell cycle; Cytotoxicity; Diagnosis, Differential; Gene expression; Gene Expression Profiling; Hematologic and hematopoietic diseases; Humans; Investigative techniques, diagnostic techniques (general aspects); Kinases; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphocytes; Lymphoma; Lymphoma, T-Cell, Peripheral - diagnosis; Lymphoma, T-Cell, Peripheral - genetics; Lymphoma, T-Cell, Peripheral - pathology; Lymphoma, T-Cell, Peripheral - therapy; Medical prognosis; Medical sciences; Morphology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Phenotype; Prognosis; Review; Tumors; Vascular endothelial growth factor; Anatomic pathology; Lymphoproliferative syndrome; Malignant hemopathy; Non Hodgkin lymphoma; Gene therapy; Peripheral T cell lymphoma; Cancer

Peripheral T cell lymphomas (PTCL) account for about 12% of lymphoid tumours worldwide. Almost half show such morphological and molecular variability as to hamper any further classification, and to justify their inclusion in a waste-basket category termed “not otherwise specified (NOS)”. The latter...