Contribution of anti-cyclic citrullinated peptide antibody and rheumatoid factor to the diagnosis of arthropathy in haemochromatosis

• Published in: Annals of the rheumatic diseases Vol. 66; no. 9; pp. 1249 - 1251
• Main Authors: Aigner, E, Schmid, I, Österreicher, C H, Zwerina, J, Schett, G, Strasser, M, Niksic, F, Hohla, F, Ramsauer, T, Dorn, U, Patsch, W, Datz, C
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and European League Against Rheumatism 01.09.2007; BMJ; Elsevier Limited; BMJ Group
• Subjects: ACR; Adolescent; Adult; Aged; American College of Rheumatology; anti-CCP; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - immunology; arthropathy; Autoantibodies - blood; Biological and medical sciences; Biomarkers - blood; Case-Control Studies; CCP; Chi-Square Distribution; Concise Report; cyclic citrullinated peptide antibodies; Diagnosis, Differential; Diseases of the osteoarticular system; Enzyme-Linked Immunosorbent Assay; Female; haemochromatosis; Health risk assessment; Hemochromatosis - blood; Hemochromatosis - complications; Hemochromatosis - immunology; Hemochromatosis Protein; hereditary haemochromatosis; HHC; Histocompatibility Antigens Class I - genetics; Homozygote; Humans; Inflammatory joint diseases; Joint Diseases - blood; Joint Diseases - etiology; Joint Diseases - immunology; Male; Medical sciences; Membrane Proteins - genetics; Metabolic diseases; Metals (hemochromatosis...); Middle Aged; Miscellaneous. Osteoarticular involvement in other diseases; Mutation; Other metabolic disorders; Patients; Peptides, Cyclic - immunology; Point Mutation; Prevalence; Rheumatism; Rheumatoid arthritis; rheumatoid factor; Rheumatoid Factor - blood; Sensitivity and Specificity; Human; Immunopathology; Hemochromatosis; Peptides; Antibody; Diseases of the osteoarticular system; Autoimmune disease; Metabolic diseases; Inflammatory joint disease; Arthritis; Iron; Joint; Enzymopathy; Rheumatoid factor; Chronic; Rheumatoid arthritis; Arthropathy; Diagnosis; ELISA assay

Objective: To investigate the prevalence of antibodies to cyclic citrullinated peptide (anti-CCP) and rheumatoid factor in patients with hereditary haemochromatosis (HHC) and to evaluate their diagnostic reliability in distinguishing HHC-associated arthropathy from rheumatoid arthritis. Methods: Ant...