Hypercholesterolaemia is not associated with early atherosclerotic lesions in primary biliary cirrhosis

• Published in: Gut Vol. 55; no. 12; pp. 1795 - 1800
• Main Authors: Allocca, M, Crosignani, A, Gritti, A, Ghilardi, G, Gobatti, D, Caruso, D, Zuin, M, Podda, M, Battezzati, P M
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.12.2006; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Age; Age Factors; Alcohol; Apo; apolipoprotein; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - complications; Atherosclerosis - diagnostic imaging; Biological and medical sciences; Blood and lymphatic vessels; BMI; body mass index; Cardiology. Vascular system; Cardiovascular disease; Carotid arteries; Carotid Arteries - diagnostic imaging; Carotid Stenosis - diagnostic imaging; Cholesterol; Cholesterol - blood; Colleges & universities; Diabetes; Disorders of blood lipids. Hyperlipoproteinemia; Female; Gastroenterology. Liver. Pancreas. Abdomen; HDL; Hepatitis; high-density lipoprotein; Humans; Hypercholesterolemia - complications; Hypercholesterolemia - diagnostic imaging; Hypertension; Hypertension - complications; IMT; interquartile range; intima–media thickness; IQR; LDL; Lipids; Liver; Liver Cirrhosis, Biliary - complications; Liver Cirrhosis, Biliary - diagnostic imaging; Liver diseases; Liver. Biliary tract. Portal circulation. Exocrine pancreas; low-density lipoprotein; Male; Medical sciences; Medicine; Metabolic diseases; Middle Aged; Mortality; Other diseases. Semiology; Patients; PBC; primary biliary cirrhosis; Risk Factors; Tunica Intima - diagnostic imaging; Ultrasonic imaging; Ultrasonography; Italy; Primary biliary cirrhosis; Cardiovascular disease; Hepatic disease; Metabolic diseases; Lipids; Hyperlipoproteinemia; Lipoprotein; Cholesterol; Vascular disease; Hypercholesterolemia; Atherosclerosis; Digestive diseases; Lesion; Dyslipemia

Background: Hypercholesterolaemia often occurs in primary biliary cirrhosis (PBC) as a result of chronic cholestasis, but whether these patients are exposed to greater cardiovascular risk is unknown. Aim: To establish whether hypercholesterolaemia is associated with subclinical atherosclerosis in PB...