Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation

• Published in: Gut Vol. 69; no. 3; pp. 513 - 522
• Main Authors: Chen, Xia, Li, Pan, Liu, Mian, Zheng, Huimin, He, Yan, Chen, Mu-Xuan, Tang, Wenli, Yue, Xiaojing, Huang, Yongxin, Zhuang, Lingling, Wang, Zhijian, Zhong, Mei, Ke, Guibao, Hu, Haoyue, Feng, Yinglin, Chen, Yun, Yu, Yanhong, Zhou, Hongwei, Huang, Liping
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.03.2020; BMJ Publishing Group LTD
• Subjects: Animals; Antibiotics; Antigens; Bacteria; Bacterial Translocation; Blood Pressure; Case-Control Studies; CD4 Lymphocyte Count; Chemokines - genetics; Creatinine; Creatinine - blood; Cytokines - genetics; Digestive system; Discriminant analysis; Disease; Disease Models, Animal; Dysbacteriosis; Dysbiosis - complications; Dysbiosis - physiopathology; Embryos; Faecalibacterium; Feces - microbiology; Female; Fetal Resorption - microbiology; Fetuses; Flow cytometry; Fusobacteria; Fusobacterium; Gastrointestinal Microbiome; Gastrointestinal tract; Gene expression; Gestation; Gut microbiota; Gynecology; Hospitals; Humans; Hybridization; Hypertension; Immune response; Immunoglobulins; immunology; Inflammation; Insulin resistance; intestinal bacteria; intestinal barrier function; Intestinal microflora; Intestine, Small - immunology; Metabolic disorders; Metabolic syndrome; Mice; Microbiomes; Microbiota; Obstetrics; Opportunist infection; Pathogenesis; Placenta; Placenta - immunology; Placenta - metabolism; Placenta - microbiology; Pre-eclampsia; Pre-Eclampsia - microbiology; Pre-Eclampsia - physiopathology; Preeclampsia; Pregnancy; Probiotics; Proteins; Proteinuria; Proteinuria - urine; RNA, Messenger - metabolism; rRNA 16S; Small intestine; Spleen; Statistical analysis; Studies; T-Lymphocytes, Regulatory; Taxonomy; Th17 Cells; Transplantation; Urine; Veillonella; United States > US; China; California; bacterial translocation; intestinal bacteria; intestinal barrier function; immunology

ObjectivePre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic diseases, but the role of gut microbiome in the pathogenesis of PE remains unknown.DesignWe performed a case–control study to compare the faecal m...